BDBM319550 8-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-2-methoxyquinoline-3-carboxamide::US10174000, Example 1

SMILES: CC[C@H]1[C@@H](COc2cccc3cc(C(N)=O)c(OC)nc23)NC(=O)[C@H]1F

InChI Key: InChIKey=KNLLETNQZOBJHR-SUHUHFCYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 319550   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM319550 (8-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-...) Show SMILES CC[C@H]1[C@@H](COc2cccc3cc(C(N)=O)c(OC)nc23)NC(=O)[C@H]1F |r| Show InChI InChI=1S/C18H20FN3O4/c1-3-10-12(21-17(24)14(10)19)8-26-13-6-4-5-9-7-11(16(20)23)18(25-2)22-15(9)13/h4-7,10,12,14H,3,8H2,1-2H3,(H2,20,23)(H,21,24)/t10-,12+,14-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...				US Patent US10174000 (2019) BindingDB Entry DOI: 10.7270/Q27S7QWQ
					More data for this Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM319550 (8-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-...) Show SMILES CC[C@H]1[C@@H](COc2cccc3cc(C(N)=O)c(OC)nc23)NC(=O)[C@H]1F |r| Show InChI InChI=1S/C18H20FN3O4/c1-3-10-12(21-17(24)14(10)19)8-26-13-6-4-5-9-7-11(16(20)23)18(25-2)22-15(9)13/h4-7,10,12,14H,3,8H2,1-2H3,(H2,20,23)(H,21,24)/t10-,12+,14-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...				US Patent US10174000 (2019) BindingDB Entry DOI: 10.7270/Q27S7QWQ
					More data for this Ligand-Target Pair