BDBM319556 4-(4,5-Dimethyl-1,3-oxazol-2-yl)-1-{[(2S)-5-oxopyrrolidin-2-yl]methoxy}-7-(propan-2-yloxy)isoquinoline-6-carboxamide::US10174000, Example 7

SMILES: CC(C)Oc1cc2c(OC[C@@H]3CCC(=O)N3)ncc(-c3nc(C)c(C)o3)c2cc1C(N)=O

InChI Key: InChIKey=FSKOPDYGVQMCOE-AWEZNQCLSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 319556   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM319556 (4-(4,5-Dimethyl-1,3-oxazol-2-yl)-1-{[(2S)-5-oxopyr...) Show SMILES CC(C)Oc1cc2c(OC[C@@H]3CCC(=O)N3)ncc(-c3nc(C)c(C)o3)c2cc1C(N)=O |r| Show InChI InChI=1S/C23H26N4O5/c1-11(2)31-19-8-16-15(7-17(19)21(24)29)18(23-26-12(3)13(4)32-23)9-25-22(16)30-10-14-5-6-20(28)27-14/h7-9,11,14H,5-6,10H2,1-4H3,(H2,24,29)(H,27,28)/t14-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...				US Patent US10174000 (2019) BindingDB Entry DOI: 10.7270/Q27S7QWQ
					More data for this Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM319556 (4-(4,5-Dimethyl-1,3-oxazol-2-yl)-1-{[(2S)-5-oxopyr...) Show SMILES CC(C)Oc1cc2c(OC[C@@H]3CCC(=O)N3)ncc(-c3nc(C)c(C)o3)c2cc1C(N)=O |r| Show InChI InChI=1S/C23H26N4O5/c1-11(2)31-19-8-16-15(7-17(19)21(24)29)18(23-26-12(3)13(4)32-23)9-25-22(16)30-10-14-5-6-20(28)27-14/h7-9,11,14H,5-6,10H2,1-4H3,(H2,24,29)(H,27,28)/t14-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	57	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...				US Patent US10174000 (2019) BindingDB Entry DOI: 10.7270/Q27S7QWQ
					More data for this Ligand-Target Pair