BindingDB PrimarySearch

BDBM319649 2-{1-[(2,4-difluorophenyl)methyl]-1H-imidazol-4- yl}-4-[5-(trifluoromethyl)-1H-1,2,3-triazol-4- yl]pyridine::US10174003, Example 68::US9896436, Example 68

SMILES: Fc1ccc(Cn2cnc(c2)-c2cc(ccn2)-c2nn[nH]c2C(F)(F)F)c(F)c1

InChI Key: InChIKey=LABVGZXSSYPADP-UHFFFAOYSA-N

Data: 8 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 319649
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM319649 (2-{1-[(2,4-difluorophenyl)methyl]-1H-imidazol-4- y...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10174003 (2019) BindingDB Entry DOI: 10.7270/Q2417053
Celgene Quanticel Research, Inc. US Patent					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM319649 (2-{1-[(2,4-difluorophenyl)methyl]-1H-imidazol-4- y...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				US Patent US10174003 (2019) BindingDB Entry DOI: 10.7270/Q2417053
Celgene Quanticel Research, Inc. US Patent					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM319649 (2-{1-[(2,4-difluorophenyl)methyl]-1H-imidazol-4- y...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10174003 (2019) BindingDB Entry DOI: 10.7270/Q2417053
Celgene Quanticel Research, Inc. US Patent					More data for this Ligand-Target Pair
Lysine-specific demethylase 6B (Homo sapiens (Human))	BDBM319649 (2-{1-[(2,4-difluorophenyl)methyl]-1H-imidazol-4- y...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The ability of test compounds to inhibit the activity of JMJD3 was determined in 384-well plate format under the following reaction conditions: 1 nM ...				Bioorg Med Chem Lett 17: 1584-9 (2007) BindingDB Entry DOI: 10.7270/Q2FT8PBQ
GSK					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM319649 (2-{1-[(2,4-difluorophenyl)methyl]-1H-imidazol-4- y...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...				Bioorg Med Chem Lett 17: 1584-9 (2007) BindingDB Entry DOI: 10.7270/Q2FT8PBQ
GSK					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM319649 (2-{1-[(2,4-difluorophenyl)methyl]-1H-imidazol-4- y...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				Bioorg Med Chem Lett 17: 1584-9 (2007) BindingDB Entry DOI: 10.7270/Q2FT8PBQ
GSK					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM319649 (2-{1-[(2,4-difluorophenyl)methyl]-1H-imidazol-4- y...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				Bioorg Med Chem Lett 17: 1584-9 (2007) BindingDB Entry DOI: 10.7270/Q2FT8PBQ
GSK					More data for this Ligand-Target Pair
Lysine-specific demethylase 6B (Homo sapiens (Human))	BDBM319649 (2-{1-[(2,4-difluorophenyl)methyl]-1H-imidazol-4- y...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD3 was determined in 384-well plate format under the following reaction conditions: 1 nM ...				US Patent US10174003 (2019) BindingDB Entry DOI: 10.7270/Q2417053
Celgene Quanticel Research, Inc. US Patent					More data for this Ligand-Target Pair