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SMILES: Cc1cc(F)ccc1Cn1cnc(c1)-c1cc(ccn1)-c1nn[nH]c1C(F)(F)F

InChI Key: InChIKey=SLSUNARBUPMOHO-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 319651   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM319651 (2-{1-[(4-fluoro-2-methylphenyl)methyl]-1H- imidazo...) Show SMILES Cc1cc(F)ccc1Cn1cnc(c1)-c1cc(ccn1)-c1nn[nH]c1C(F)(F)F Show InChI InChI=1S/C19H14F4N6/c1-11-6-14(20)3-2-13(11)8-29-9-16(25-10-29)15-7-12(4-5-24-15)17-18(19(21,22)23)27-28-26-17/h2-7,9-10H,8H2,1H3,(H,26,27,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10174003 (2019) BindingDB Entry DOI: 10.7270/Q2417053
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM319651 (2-{1-[(4-fluoro-2-methylphenyl)methyl]-1H- imidazo...) Show SMILES Cc1cc(F)ccc1Cn1cnc(c1)-c1cc(ccn1)-c1nn[nH]c1C(F)(F)F Show InChI InChI=1S/C19H14F4N6/c1-11-6-14(20)3-2-13(11)8-29-9-16(25-10-29)15-7-12(4-5-24-15)17-18(19(21,22)23)27-28-26-17/h2-7,9-10H,8H2,1H3,(H,26,27,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				US Patent US10174003 (2019) BindingDB Entry DOI: 10.7270/Q2417053
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM319651 (2-{1-[(4-fluoro-2-methylphenyl)methyl]-1H- imidazo...) Show SMILES Cc1cc(F)ccc1Cn1cnc(c1)-c1cc(ccn1)-c1nn[nH]c1C(F)(F)F Show InChI InChI=1S/C19H14F4N6/c1-11-6-14(20)3-2-13(11)8-29-9-16(25-10-29)15-7-12(4-5-24-15)17-18(19(21,22)23)27-28-26-17/h2-7,9-10H,8H2,1H3,(H,26,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10174003 (2019) BindingDB Entry DOI: 10.7270/Q2417053
					More data for this Ligand-Target Pair
Lysine-specific demethylase 6B (Homo sapiens (Human))	BDBM319651 (2-{1-[(4-fluoro-2-methylphenyl)methyl]-1H- imidazo...) Show SMILES Cc1cc(F)ccc1Cn1cnc(c1)-c1cc(ccn1)-c1nn[nH]c1C(F)(F)F Show InChI InChI=1S/C19H14F4N6/c1-11-6-14(20)3-2-13(11)8-29-9-16(25-10-29)15-7-12(4-5-24-15)17-18(19(21,22)23)27-28-26-17/h2-7,9-10H,8H2,1H3,(H,26,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The ability of test compounds to inhibit the activity of JMJD3 was determined in 384-well plate format under the following reaction conditions: 1 nM ...				Bioorg Med Chem Lett 17: 1584-9 (2007) BindingDB Entry DOI: 10.7270/Q2FT8PBQ
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM319651 (2-{1-[(4-fluoro-2-methylphenyl)methyl]-1H- imidazo...) Show SMILES Cc1cc(F)ccc1Cn1cnc(c1)-c1cc(ccn1)-c1nn[nH]c1C(F)(F)F Show InChI InChI=1S/C19H14F4N6/c1-11-6-14(20)3-2-13(11)8-29-9-16(25-10-29)15-7-12(4-5-24-15)17-18(19(21,22)23)27-28-26-17/h2-7,9-10H,8H2,1H3,(H,26,27,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...				Bioorg Med Chem Lett 17: 1584-9 (2007) BindingDB Entry DOI: 10.7270/Q2FT8PBQ
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM319651 (2-{1-[(4-fluoro-2-methylphenyl)methyl]-1H- imidazo...) Show SMILES Cc1cc(F)ccc1Cn1cnc(c1)-c1cc(ccn1)-c1nn[nH]c1C(F)(F)F Show InChI InChI=1S/C19H14F4N6/c1-11-6-14(20)3-2-13(11)8-29-9-16(25-10-29)15-7-12(4-5-24-15)17-18(19(21,22)23)27-28-26-17/h2-7,9-10H,8H2,1H3,(H,26,27,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				Bioorg Med Chem Lett 17: 1584-9 (2007) BindingDB Entry DOI: 10.7270/Q2FT8PBQ
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM319651 (2-{1-[(4-fluoro-2-methylphenyl)methyl]-1H- imidazo...) Show SMILES Cc1cc(F)ccc1Cn1cnc(c1)-c1cc(ccn1)-c1nn[nH]c1C(F)(F)F Show InChI InChI=1S/C19H14F4N6/c1-11-6-14(20)3-2-13(11)8-29-9-16(25-10-29)15-7-12(4-5-24-15)17-18(19(21,22)23)27-28-26-17/h2-7,9-10H,8H2,1H3,(H,26,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				Bioorg Med Chem Lett 17: 1584-9 (2007) BindingDB Entry DOI: 10.7270/Q2FT8PBQ
					More data for this Ligand-Target Pair
Lysine-specific demethylase 6B (Homo sapiens (Human))	BDBM319651 (2-{1-[(4-fluoro-2-methylphenyl)methyl]-1H- imidazo...) Show SMILES Cc1cc(F)ccc1Cn1cnc(c1)-c1cc(ccn1)-c1nn[nH]c1C(F)(F)F Show InChI InChI=1S/C19H14F4N6/c1-11-6-14(20)3-2-13(11)8-29-9-16(25-10-29)15-7-12(4-5-24-15)17-18(19(21,22)23)27-28-26-17/h2-7,9-10H,8H2,1H3,(H,26,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD3 was determined in 384-well plate format under the following reaction conditions: 1 nM ...				US Patent US10174003 (2019) BindingDB Entry DOI: 10.7270/Q2417053
					More data for this Ligand-Target Pair