null

SMILES: CC(C)n1c(nc2c(c(Br)c(Br)cc12)[N+]([O-])=O)N1CCNCC1

InChI Key: InChIKey=OXXGIJXWBGSRMV-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 319787   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-type tyrosine-protein kinase FLT3 [K633Q] (Homo sapiens (Human))	BDBM319787 (5,6-dibromo-4-nitro-2-(piperazin-1-yl)-1-(propan-2...) Show SMILES CC(C)n1c(nc2c(c(Br)c(Br)cc12)[N+]([O-])=O)N1CCNCC1 Show InChI InChI=1S/C14H17Br2N5O2/c1-8(2)20-10-7-9(15)11(16)13(21(22)23)12(10)18-14(20)19-5-3-17-4-6-19/h7-8,17H,3-6H2,1-2H3	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a
SELVITA S.A. US Patent					Assay Description Selected compounds were also tested for their binding properties against FLT3 kinase mutants using suitable in vitro assays (performed according to s...				US Patent US10174013 (2019) BindingDB Entry DOI: 10.7270/Q2QR5069
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM319787 (5,6-dibromo-4-nitro-2-(piperazin-1-yl)-1-(propan-2...) Show SMILES CC(C)n1c(nc2c(c(Br)c(Br)cc12)[N+]([O-])=O)N1CCNCC1 Show InChI InChI=1S/C14H17Br2N5O2/c1-8(2)20-10-7-9(15)11(16)13(21(22)23)12(10)18-14(20)19-5-3-17-4-6-19/h7-8,17H,3-6H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a
SELVITA S.A. US Patent					Assay Description Selected compounds were also tested for their binding properties against FLT3 kinase mutants using suitable in vitro assays (performed according to s...				US Patent US10174013 (2019) BindingDB Entry DOI: 10.7270/Q2QR5069
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835H] (Homo sapiens (Human))	BDBM319787 (5,6-dibromo-4-nitro-2-(piperazin-1-yl)-1-(propan-2...) Show SMILES CC(C)n1c(nc2c(c(Br)c(Br)cc12)[N+]([O-])=O)N1CCNCC1 Show InChI InChI=1S/C14H17Br2N5O2/c1-8(2)20-10-7-9(15)11(16)13(21(22)23)12(10)18-14(20)19-5-3-17-4-6-19/h7-8,17H,3-6H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a
SELVITA S.A. US Patent					Assay Description Selected compounds were also tested for their binding properties against FLT3 kinase mutants using suitable in vitro assays (performed according to s...				US Patent US10174013 (2019) BindingDB Entry DOI: 10.7270/Q2QR5069
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [K633Q] (Homo sapiens (Human))	BDBM319787 (5,6-dibromo-4-nitro-2-(piperazin-1-yl)-1-(propan-2...) Show SMILES CC(C)n1c(nc2c(c(Br)c(Br)cc12)[N+]([O-])=O)N1CCNCC1 Show InChI InChI=1S/C14H17Br2N5O2/c1-8(2)20-10-7-9(15)11(16)13(21(22)23)12(10)18-14(20)19-5-3-17-4-6-19/h7-8,17H,3-6H2,1-2H3	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a
SELVITA S.A. US Patent					Assay Description Selected compounds were also tested for their binding properties against FLT3 kinase mutants using suitable in vitro assays (performed according to s...				US Patent US10174013 (2019) BindingDB Entry DOI: 10.7270/Q2QR5069
					More data for this Ligand-Target Pair