BDBM319839 N-[1-(5-Chloro-3-fluoropyridin-2-yl)ethyl]-3-(cyclopropylmethoxy)-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 6::US10202369, Example 6::US10472354, Example 6
SMILES: CC(NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F
InChI Key: InChIKey=YIPUFXDTAKNGSX-UHFFFAOYSA-N
Data: 8 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
P2X purinoceptor 3 (Homo sapiens (Human)) | BDBM319839 (N-[1-(5-Chloro-3-fluoropyridin-2-yl)ethyl]-3-(cycl...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Aktiengesellschaft US Patent | Assay Description A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati... | US Patent US10183937 (2019) BindingDB Entry DOI: 10.7270/Q2028TNS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 2 (Homo sapiens (Human)) | BDBM319839 (N-[1-(5-Chloro-3-fluoropyridin-2-yl)ethyl]-3-(cycl...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Aktiengesellschaft US Patent | Assay Description A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati... | US Patent US10183937 (2019) BindingDB Entry DOI: 10.7270/Q2028TNS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 3 (Homo sapiens (Human)) | BDBM319839 (N-[1-(5-Chloro-3-fluoropyridin-2-yl)ethyl]-3-(cycl...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
BEYER AKTIENGESELLSCHAFT US Patent | Assay Description A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati... | US Patent US10174016 (2019) BindingDB Entry DOI: 10.7270/Q2GB264F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X2/3 (Homo sapiens (Human)) | BDBM319839 (N-[1-(5-Chloro-3-fluoropyridin-2-yl)ethyl]-3-(cycl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Aktiengesellschaft US Patent | Assay Description A fluorescent imaging plate reader (FILEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelat... | US Patent US10472354 (2019) BindingDB Entry DOI: 10.7270/Q2KD2197 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 3 (Homo sapiens (Human)) | BDBM319839 (N-[1-(5-Chloro-3-fluoropyridin-2-yl)ethyl]-3-(cycl...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Aktiengesellschaft US Patent | Assay Description A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati... | US Patent US10202369 (2019) BindingDB Entry DOI: 10.7270/Q2TT4T2P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X2/3 (Homo sapiens (Human)) | BDBM319839 (N-[1-(5-Chloro-3-fluoropyridin-2-yl)ethyl]-3-(cycl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Aktiengesellschaft US Patent | Assay Description A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati... | US Patent US10202369 (2019) BindingDB Entry DOI: 10.7270/Q2TT4T2P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 3 (Homo sapiens (Human)) | BDBM319839 (N-[1-(5-Chloro-3-fluoropyridin-2-yl)ethyl]-3-(cycl...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Aktiengesellschaft US Patent | Assay Description A fluorescent imaging plate reader (FILEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelat... | US Patent US10472354 (2019) BindingDB Entry DOI: 10.7270/Q2KD2197 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 2 (Homo sapiens (Human)) | BDBM319839 (N-[1-(5-Chloro-3-fluoropyridin-2-yl)ethyl]-3-(cycl...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
BEYER AKTIENGESELLSCHAFT US Patent | Assay Description A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati... | US Patent US10174016 (2019) BindingDB Entry DOI: 10.7270/Q2GB264F | |||||||||||
More data for this Ligand-Target Pair |