BDBM320052 3-{[(4aS,7S, 7aR)-4- methylocta- hydro- cyclopenta[b] [1,4]oxazin- 7-yl]oxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 219::US10202369, Example 219::US10472354, Example 219
SMILES: C[C@@H](NC(=O)c1cc(O[C@H]2CC[C@H]3[C@H]2OCCN3C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F
InChI Key: InChIKey=FEZSJTOXTJNSGQ-NSEXGNSCSA-N
Data: 8 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
P2X purinoceptor 3 (Homo sapiens (Human)) | BDBM320052 (3-{[(4aS,7S, 7aR)-4- methylocta- hydro- cyclopenta...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Aktiengesellschaft US Patent | Assay Description A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati... | US Patent US10183937 (2019) BindingDB Entry DOI: 10.7270/Q2028TNS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 2 (Homo sapiens (Human)) | BDBM320052 (3-{[(4aS,7S, 7aR)-4- methylocta- hydro- cyclopenta...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 199 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Aktiengesellschaft US Patent | Assay Description A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati... | US Patent US10183937 (2019) BindingDB Entry DOI: 10.7270/Q2028TNS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 3 (Homo sapiens (Human)) | BDBM320052 (3-{[(4aS,7S, 7aR)-4- methylocta- hydro- cyclopenta...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
BEYER AKTIENGESELLSCHAFT US Patent | Assay Description A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati... | US Patent US10174016 (2019) BindingDB Entry DOI: 10.7270/Q2GB264F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X2/3 (Homo sapiens (Human)) | BDBM320052 (3-{[(4aS,7S, 7aR)-4- methylocta- hydro- cyclopenta...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 199 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Aktiengesellschaft US Patent | Assay Description A fluorescent imaging plate reader (FILEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelat... | US Patent US10472354 (2019) BindingDB Entry DOI: 10.7270/Q2KD2197 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 3 (Homo sapiens (Human)) | BDBM320052 (3-{[(4aS,7S, 7aR)-4- methylocta- hydro- cyclopenta...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Aktiengesellschaft US Patent | Assay Description A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati... | US Patent US10202369 (2019) BindingDB Entry DOI: 10.7270/Q2TT4T2P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X2/3 (Homo sapiens (Human)) | BDBM320052 (3-{[(4aS,7S, 7aR)-4- methylocta- hydro- cyclopenta...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 199 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Aktiengesellschaft US Patent | Assay Description A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati... | US Patent US10202369 (2019) BindingDB Entry DOI: 10.7270/Q2TT4T2P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 3 (Homo sapiens (Human)) | BDBM320052 (3-{[(4aS,7S, 7aR)-4- methylocta- hydro- cyclopenta...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Aktiengesellschaft US Patent | Assay Description A fluorescent imaging plate reader (FILEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelat... | US Patent US10472354 (2019) BindingDB Entry DOI: 10.7270/Q2KD2197 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 2 (Homo sapiens (Human)) | BDBM320052 (3-{[(4aS,7S, 7aR)-4- methylocta- hydro- cyclopenta...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 199 | n/a | n/a | n/a | n/a | n/a | n/a |
BEYER AKTIENGESELLSCHAFT US Patent | Assay Description A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati... | US Patent US10174016 (2019) BindingDB Entry DOI: 10.7270/Q2GB264F | |||||||||||
More data for this Ligand-Target Pair |