BDBM320446 2-(3,4-difluorobenzyl)-1H- pyrrolo[3,2-b]pyridine-7- carboxylic acid::US10174026, Example 126::US9738637, Example 126

SMILES: OC(=O)c1ccnc2cc(Cc3ccc(F)c(F)c3)[nH]c12

InChI Key: InChIKey=GJWWRHMMSBHKOT-UHFFFAOYSA-N

Data: 8 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 320446   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM320446 (2-(3,4-difluorobenzyl)-1H- pyrrolo[3,2-b]pyridine-...) Show SMILES OC(=O)c1ccnc2cc(Cc3ccc(F)c(F)c3)[nH]c12 Show InChI InChI=1S/C15H10F2N2O2/c16-11-2-1-8(6-12(11)17)5-9-7-13-14(19-9)10(15(20)21)3-4-18-13/h1-4,6-7,19H,5H2,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...				US Patent US10174026 (2019) BindingDB Entry DOI: 10.7270/Q2Z89FG4
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM320446 (2-(3,4-difluorobenzyl)-1H- pyrrolo[3,2-b]pyridine-...) Show SMILES OC(=O)c1ccnc2cc(Cc3ccc(F)c(F)c3)[nH]c12 Show InChI InChI=1S/C15H10F2N2O2/c16-11-2-1-8(6-12(11)17)5-9-7-13-14(19-9)10(15(20)21)3-4-18-13/h1-4,6-7,19H,5H2,(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				US Patent US10174026 (2019) BindingDB Entry DOI: 10.7270/Q2Z89FG4
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM320446 (2-(3,4-difluorobenzyl)-1H- pyrrolo[3,2-b]pyridine-...) Show SMILES OC(=O)c1ccnc2cc(Cc3ccc(F)c(F)c3)[nH]c12 Show InChI InChI=1S/C15H10F2N2O2/c16-11-2-1-8(6-12(11)17)5-9-7-13-14(19-9)10(15(20)21)3-4-18-13/h1-4,6-7,19H,5H2,(H,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10174026 (2019) BindingDB Entry DOI: 10.7270/Q2Z89FG4
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4A (Homo sapiens (Human))	BDBM320446 (2-(3,4-difluorobenzyl)-1H- pyrrolo[3,2-b]pyridine-...) Show SMILES OC(=O)c1ccnc2cc(Cc3ccc(F)c(F)c3)[nH]c12 Show InChI InChI=1S/C15H10F2N2O2/c16-11-2-1-8(6-12(11)17)5-9-7-13-14(19-9)10(15(20)21)3-4-18-13/h1-4,6-7,19H,5H2,(H,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quantical Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2A was determined in 384-well plate format under the following reaction conditions: 2 nM...				US Patent US9738637 (2017) BindingDB Entry DOI: 10.7270/Q2VD71K6
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM320446 (2-(3,4-difluorobenzyl)-1H- pyrrolo[3,2-b]pyridine-...) Show SMILES OC(=O)c1ccnc2cc(Cc3ccc(F)c(F)c3)[nH]c12 Show InChI InChI=1S/C15H10F2N2O2/c16-11-2-1-8(6-12(11)17)5-9-7-13-14(19-9)10(15(20)21)3-4-18-13/h1-4,6-7,19H,5H2,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quantical Research, Inc. US Patent					Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...				US Patent US9738637 (2017) BindingDB Entry DOI: 10.7270/Q2VD71K6
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM320446 (2-(3,4-difluorobenzyl)-1H- pyrrolo[3,2-b]pyridine-...) Show SMILES OC(=O)c1ccnc2cc(Cc3ccc(F)c(F)c3)[nH]c12 Show InChI InChI=1S/C15H10F2N2O2/c16-11-2-1-8(6-12(11)17)5-9-7-13-14(19-9)10(15(20)21)3-4-18-13/h1-4,6-7,19H,5H2,(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quantical Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				US Patent US9738637 (2017) BindingDB Entry DOI: 10.7270/Q2VD71K6
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM320446 (2-(3,4-difluorobenzyl)-1H- pyrrolo[3,2-b]pyridine-...) Show SMILES OC(=O)c1ccnc2cc(Cc3ccc(F)c(F)c3)[nH]c12 Show InChI InChI=1S/C15H10F2N2O2/c16-11-2-1-8(6-12(11)17)5-9-7-13-14(19-9)10(15(20)21)3-4-18-13/h1-4,6-7,19H,5H2,(H,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quantical Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US9738637 (2017) BindingDB Entry DOI: 10.7270/Q2VD71K6
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4A (Homo sapiens (Human))	BDBM320446 (2-(3,4-difluorobenzyl)-1H- pyrrolo[3,2-b]pyridine-...) Show SMILES OC(=O)c1ccnc2cc(Cc3ccc(F)c(F)c3)[nH]c12 Show InChI InChI=1S/C15H10F2N2O2/c16-11-2-1-8(6-12(11)17)5-9-7-13-14(19-9)10(15(20)21)3-4-18-13/h1-4,6-7,19H,5H2,(H,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2A was determined in 384-well plate format under the following reaction conditions: 2 nM...				US Patent US10174026 (2019) BindingDB Entry DOI: 10.7270/Q2Z89FG4
					More data for this Ligand-Target Pair