BDBM320656 (R)- or (S)-6-Dimethylamino)-3- (hydroxymethyl)-1-(2-methyl-1-(4- (trifluoromethyl)phenyl)propyl)-1H- pyrazolo[3,4-d]pyrimidin-4(5H)-one::US10174037, Example 64::US10174037, Example 65

SMILES: CC(C)C(c1ccc(cc1)C(F)(F)F)n1nc(CO)c2c1nc([nH]c2=O)N(C)C

InChI Key:

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 320656   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human))	BDBM320656 ((R)- or (S)-6-Dimethylamino)-3- (hydroxymethyl)-1-...) Show SMILES CC(C)C(c1ccc(cc1)C(F)(F)F)n1nc(CO)c2c1nc([nH]c2=O)N(C)C Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0690	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...				US Patent US10174037 (2019) BindingDB Entry DOI: 10.7270/Q29K4DB7
					More data for this Ligand-Target Pair
Phosphodiesterase (Macaca mulatta (Rhesus macaque))	BDBM320656 ((R)- or (S)-6-Dimethylamino)-3- (hydroxymethyl)-1-...) Show SMILES CC(C)C(c1ccc(cc1)C(F)(F)F)n1nc(CO)c2c1nc([nH]c2=O)N(C)C Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0760	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...				US Patent US10174037 (2019) BindingDB Entry DOI: 10.7270/Q29K4DB7
					More data for this Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human))	BDBM320656 ((R)- or (S)-6-Dimethylamino)-3- (hydroxymethyl)-1-...) Show SMILES CC(C)C(c1ccc(cc1)C(F)(F)F)n1nc(CO)c2c1nc([nH]c2=O)N(C)C Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.290	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...				US Patent US10174037 (2019) BindingDB Entry DOI: 10.7270/Q29K4DB7
					More data for this Ligand-Target Pair
Phosphodiesterase (Macaca mulatta (Rhesus macaque))	BDBM320656 ((R)- or (S)-6-Dimethylamino)-3- (hydroxymethyl)-1-...) Show SMILES CC(C)C(c1ccc(cc1)C(F)(F)F)n1nc(CO)c2c1nc([nH]c2=O)N(C)C Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.390	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...				US Patent US10174037 (2019) BindingDB Entry DOI: 10.7270/Q29K4DB7
					More data for this Ligand-Target Pair