BDBM320811 (R)- or (S)-1-(1-(4-(1,1-Difluoroethyl)-3- fluorophenyl)propyl)-6-(dimethylamino)-3- (fluoromethyl)-1H-pyrazolo[3,4- d]pyrimidin-4(5H)-one::US10174037, Example 216::US10174037, Example 217
SMILES: CCC(c1ccc(c(F)c1)C(C)(F)F)n1nc(CF)c2c1nc([nH]c2=O)N(C)C
InChI Key:
Data: 4 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human)) | BDBM320811 ((R)- or (S)-1-(1-(4-(1,1-Difluoroethyl)-3- fluorop...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor... | US Patent US10174037 (2019) BindingDB Entry DOI: 10.7270/Q29K4DB7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM320811 ((R)- or (S)-1-(1-(4-(1,1-Difluoroethyl)-3- fluorop...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0270 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor... | US Patent US10174037 (2019) BindingDB Entry DOI: 10.7270/Q29K4DB7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human)) | BDBM320811 ((R)- or (S)-1-(1-(4-(1,1-Difluoroethyl)-3- fluorop...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor... | US Patent US10174037 (2019) BindingDB Entry DOI: 10.7270/Q29K4DB7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM320811 ((R)- or (S)-1-(1-(4-(1,1-Difluoroethyl)-3- fluorop...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor... | US Patent US10174037 (2019) BindingDB Entry DOI: 10.7270/Q29K4DB7 | |||||||||||
More data for this Ligand-Target Pair |