Found 23 hits for monomerid = 32203 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Thermolysin
(Bacillus thermoproteolyticus) | BDBM32203
(8-quinolinol | CHEMBL310555 | US10005735, Table 1....)Show InChI InChI=1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
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Similars
| Article PubMed
| 2.14E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tromsø
Curated by ChEMBL
| Assay Description Inhibition of Bacillus thermoproteolyticus thermolysin |
J Med Chem 52: 48-61 (2009)
Article DOI: 10.1021/jm8008019 BindingDB Entry DOI: 10.7270/Q28P60BR |
More data for this Ligand-Target Pair | |
Lanosterol synthase
(Rattus norvegicus) | BDBM32203
(8-quinolinol | CHEMBL310555 | US10005735, Table 1....)Show InChI InChI=1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
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| Article PubMed
| n/a | n/a | 1.59E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Lieber Institute for Brain Development
Curated by ChEMBL
| Assay Description Inhibition of c-terminal hexa-His tagged human MB-COMT expressed in HEK293 cell membrane homogenate using norepinephrine as substrate after 1 hr in p... |
J Med Chem 61: 9647-9665 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01126 BindingDB Entry DOI: 10.7270/Q2N300H8 |
More data for this Ligand-Target Pair | |
Heat shock protein HSP 90-alpha
(Homo sapiens (Human)) | BDBM32203
(8-quinolinol | CHEMBL310555 | US10005735, Table 1....)Show InChI InChI=1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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| PCBioAssay
| n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Emory University Molecular Libraries Screening Center
Curated by PubChem BioAssay
| Assay Description A fluorescence polarization based HTS assay has been developed and optimized for the identification of Hsp90 inhibitors by using tumor cell lysate Hs... |
PubChem Bioassay (2007)
BindingDB Entry DOI: 10.7270/Q2Q23XM6 |
More data for this Ligand-Target Pair | |
Fructose-1,6-bisphosphate aldolase (FBA)
(Mycobacterium tuberculosis (strain H37Rv)) | BDBM32203
(8-quinolinol | CHEMBL310555 | US10005735, Table 1....)Show InChI InChI=1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H | PDB
UniProtKB/SwissProt
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| US Patent
| n/a | n/a | 3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Denver and Regis University
US Patent
| Assay Description Enzymatic activity is measured by contacting the enzyme with a suitable substrate, such as fructose 1,6-bisphosphate, and measuring formation of a pr... |
US Patent US9394254 (2016)
BindingDB Entry DOI: 10.7270/Q2251H3W |
More data for this Ligand-Target Pair | |
Thermolysin
(Bacillus thermoproteolyticus) | BDBM32203
(8-quinolinol | CHEMBL310555 | US10005735, Table 1....)Show InChI InChI=1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H | PDB MMDB
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 3.50E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tromsø
Curated by ChEMBL
| Assay Description Inhibition of Bacillus thermoproteolyticus thermolysin |
J Med Chem 52: 48-61 (2009)
Article DOI: 10.1021/jm8008019 BindingDB Entry DOI: 10.7270/Q28P60BR |
More data for this Ligand-Target Pair | |
Acetylcholinesterase
(Homo sapiens (Human)) | BDBM32203
(8-quinolinol | CHEMBL310555 | US10005735, Table 1....)Show InChI InChI=1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto de Quimica Medica
Curated by ChEMBL
| Assay Description Inhibition of human erythrocyte AChE by Ellman's reaction |
J Med Chem 53: 4927-37 (2010)
Article DOI: 10.1021/jm100329q BindingDB Entry DOI: 10.7270/Q22Z15QR |
More data for this Ligand-Target Pair | |
Cholinesterases
(Homo sapiens (Human)) | BDBM32203
(8-quinolinol | CHEMBL310555 | US10005735, Table 1....)Show InChI InChI=1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto de Quimica Medica
Curated by ChEMBL
| Assay Description Inhibition of human serum BChE by Ellman's reaction |
J Med Chem 53: 4927-37 (2010)
Article DOI: 10.1021/jm100329q BindingDB Entry DOI: 10.7270/Q22Z15QR |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM32203
(8-quinolinol | CHEMBL310555 | US10005735, Table 1....)Show InChI InChI=1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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| Article PubMed
| n/a | n/a | 1.30E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MMP2 after 30 mins |
J Med Chem 54: 591-602 (2011)
Article DOI: 10.1021/jm101266s BindingDB Entry DOI: 10.7270/Q2154HBV |
More data for this Ligand-Target Pair | |
LDL-associated phospholipase A2
(Homo sapiens (Human)) | BDBM32203
(8-quinolinol | CHEMBL310555 | US10005735, Table 1....)Show InChI InChI=1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human plasma lipoprotein-associated phospholipase A2 using 2-thio-PAF as substrate preincubated for 20 mins measured 1 hr post substrat... |
Bioorg Med Chem Lett 22: 868-71 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.045 BindingDB Entry DOI: 10.7270/Q2XG9RMD |
More data for this Ligand-Target Pair | |
LDL-associated phospholipase A2
(Homo sapiens (Human)) | BDBM32203
(8-quinolinol | CHEMBL310555 | US10005735, Table 1....)Show InChI InChI=1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human plasma lipoprotein-associated phospholipase A2 using 2-thio-PAF as substrate preincubated for 20 mins measured 1 hr post substrat... |
Bioorg Med Chem Lett 22: 868-71 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.045 BindingDB Entry DOI: 10.7270/Q2XG9RMD |
More data for this Ligand-Target Pair | |
Botulinum neurotoxin type A
(Clostridium botulinum) | BDBM32203
(8-quinolinol | CHEMBL310555 | US10005735, Table 1....)Show InChI InChI=1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H | PDB MMDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute
Curated by ChEMBL
| Assay Description Inhibition of Clostridium botulinum BoNT/A LC expressed in Escherichia coli assessed as cleavage of SNAPtide preincubated for 5 mins followed by SNAP... |
J Med Chem 57: 669-76 (2014)
Article DOI: 10.1021/jm4012164 BindingDB Entry DOI: 10.7270/Q2GH9KDZ |
More data for this Ligand-Target Pair | |
Indoleamine 2,3-dioxygenase
(Homo sapiens (Human)) | BDBM32203
(8-quinolinol | CHEMBL310555 | US10005735, Table 1....)Show InChI InChI=1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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| Article PubMed
| n/a | n/a | 7.50E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Cancer Research
Curated by ChEMBL
| Assay Description Inhibition of human recombinant IDO expressed in Escherichia coli BL21 AI |
J Med Chem 53: 1172-89 (2010)
Article DOI: 10.1021/jm9014718 BindingDB Entry DOI: 10.7270/Q2BC40G9 |
More data for this Ligand-Target Pair | |
Methionine Aminopeptidase Type 1 (MetAP1)
(Homo sapiens (Human)) | BDBM32203
(8-quinolinol | CHEMBL310555 | US10005735, Table 1....)Show InChI InChI=1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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Patents
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| Article PubMed
| n/a | n/a | 2.15E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Heidelberg
Curated by ChEMBL
| Assay Description Inhibition of human MetAP1 |
Bioorg Med Chem Lett 20: 4038-44 (2010)
Article DOI: 10.1016/j.bmcl.2010.05.093 BindingDB Entry DOI: 10.7270/Q2RF5W0K |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM32203
(8-quinolinol | CHEMBL310555 | US10005735, Table 1....)Show InChI InChI=1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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Patents
Similars
| Article PubMed
| n/a | n/a | 5.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Heidelberg
Curated by ChEMBL
| Assay Description Inhibition of human MetAP2 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 20: 4038-44 (2010)
Article DOI: 10.1016/j.bmcl.2010.05.093 BindingDB Entry DOI: 10.7270/Q2RF5W0K |
More data for this Ligand-Target Pair | |
Methionine Aminopeptidase Type 1 (MetAP1)
(Homo sapiens (Human)) | BDBM32203
(8-quinolinol | CHEMBL310555 | US10005735, Table 1....)Show InChI InChI=1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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Patents
Similars
| Article PubMed
| n/a | n/a | 1.29E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Northern Illinois University
Curated by ChEMBL
| Assay Description Inhibition of recombinant full length human His-tagged methionine aminopeptidase 1 expressed in Escherichia coli BL21(DE3) using methionylprolyl-p-ni... |
Bioorg Med Chem 25: 813-824 (2017)
Article DOI: 10.1016/j.bmc.2016.11.013 BindingDB Entry DOI: 10.7270/Q2125VV2 |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM32203
(8-quinolinol | CHEMBL310555 | US10005735, Table 1....)Show InChI InChI=1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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Patents
Similars
| Article PubMed
| n/a | n/a | 1.27E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Northern Illinois University
Curated by ChEMBL
| Assay Description Inhibition of recombinant full length human N-terminal GST/His6-tagged methionine aminopeptidase 2 expressed in baculovirus infected sf9 cells using ... |
Bioorg Med Chem 25: 813-824 (2017)
Article DOI: 10.1016/j.bmc.2016.11.013 BindingDB Entry DOI: 10.7270/Q2125VV2 |
More data for this Ligand-Target Pair | |
Botulinum neurotoxin type A
(Clostridium botulinum) | BDBM32203
(8-quinolinol | CHEMBL310555 | US10005735, Table 1....)Show InChI InChI=1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H | PDB MMDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
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Patents
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| PubMed
| n/a | n/a | 3.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
U.S. Army Medical Research Institute of Infectious Diseases
Curated by ChEMBL
| Assay Description Inhibition of protease activity of recombinant full length Clostridium botulinum Hall BoNT/A light chain using SNAP-25 peptide (187 to 203 residues) ... |
Bioorg Med Chem Lett 27: 675-678 (2017)
BindingDB Entry DOI: 10.7270/Q2NP26PM |
More data for this Ligand-Target Pair | |
Bile salt export pump
(Homo sapiens (Human)) | BDBM32203
(8-quinolinol | CHEMBL310555 | US10005735, Table 1....)Show InChI InChI=1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-... |
Drug Metab Dispos 40: 2332-41 (2012)
Article DOI: 10.1124/dmd.112.047068 BindingDB Entry DOI: 10.7270/Q2ZP488M |
More data for this Ligand-Target Pair | |
26S Proteasome regulatory subunit Rpn11 (Rpn11)
(Homo sapiens (Human)) | BDBM32203
(8-quinolinol | CHEMBL310555 | US10005735, Table 1....)Show InChI InChI=1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
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Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California San Diego
Curated by ChEMBL
| Assay Description Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ... |
J Med Chem 60: 1343-1361 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01379 BindingDB Entry DOI: 10.7270/Q22F7QX5 |
More data for this Ligand-Target Pair | |
26S Proteasome regulatory subunit Rpn11 (Rpn11)
(Homo sapiens (Human)) | BDBM32203
(8-quinolinol | CHEMBL310555 | US10005735, Table 1....)Show InChI InChI=1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
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Patents
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| US Patent
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
| Assay Description In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i... |
Bioorg Med Chem 17: 8086-92 (2009)
BindingDB Entry DOI: 10.7270/Q22R3V09 |
More data for this Ligand-Target Pair | |
Lanosterol synthase
(Rattus norvegicus) | BDBM32203
(8-quinolinol | CHEMBL310555 | US10005735, Table 1....)Show InChI InChI=1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H | PDB
KEGG
UniProtKB/SwissProt
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Patents
Similars
| Article PubMed
| n/a | n/a | 3.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Lieber Institute for Brain Development
Curated by ChEMBL
| Assay Description Inhibition of c-terminal hexa-His tagged human MB-COMT (unknown origin) |
J Med Chem 61: 9647-9665 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01126 BindingDB Entry DOI: 10.7270/Q2N300H8 |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM32203
(8-quinolinol | CHEMBL310555 | US10005735, Table 1....)Show InChI InChI=1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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Patents
Similars
| Article PubMed
| n/a | n/a | 2.03E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Northern Illinois University
Curated by ChEMBL
| Assay Description Inhibition of human methionine aminopeptidase 2 |
ACS Med Chem Lett 4: (2013)
Article DOI: 10.1021/ml400034m BindingDB Entry DOI: 10.7270/Q2XW4M72 |
More data for this Ligand-Target Pair | |
Methionine Aminopeptidase Type 1 (MetAP1)
(Homo sapiens (Human)) | BDBM32203
(8-quinolinol | CHEMBL310555 | US10005735, Table 1....)Show InChI InChI=1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Northern Illinois University
Curated by ChEMBL
| Assay Description Inhibition of human methionine aminopeptidase 1 |
ACS Med Chem Lett 4: (2013)
Article DOI: 10.1021/ml400034m BindingDB Entry DOI: 10.7270/Q2XW4M72 |
More data for this Ligand-Target Pair | |