BDBM322298 6-cyclopropyl-N-(1''-azaspiro[cyclopropane-1,2''-bicyclo[2.2.2]octan]-3''-yl)benzo[b]thiophene-2-carboxamide::US10183938, Compound 71a::US10183938, Compound 71b

SMILES: O=C(NC1C2CCN(CC2)C11CC1)c1cc2ccc(cc2s1)C1CC1

InChI Key: InChIKey=MGTLCRSMMGOQIY-UHFFFAOYSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 322298   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Neuronal acetylcholine receptor protein alpha-7 subunit (Homo sapiens (Human))	BDBM322298 (6-cyclopropyl-N-(1''-azaspiro[cyclopropane-1,2''-b...) Show SMILES O=C(NC1C2CCN(CC2)C11CC1)c1cc2ccc(cc2s1)C1CC1 Show InChI InChI=1S/C21H24N2OS/c24-20(22-19-14-5-9-23(10-6-14)21(19)7-8-21)18-12-16-4-3-15(13-1-2-13)11-17(16)25-18/h3-4,11-14,19H,1-2,5-10H2,(H,22,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	210	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Axovant Sciences GmbH US Patent					Assay Description The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp...				US Patent US10183938 (2019) BindingDB Entry DOI: 10.7270/Q2VD71JR
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 3A (Homo sapiens (Human))	BDBM322298 (6-cyclopropyl-N-(1''-azaspiro[cyclopropane-1,2''-b...) Show SMILES O=C(NC1C2CCN(CC2)C11CC1)c1cc2ccc(cc2s1)C1CC1 Show InChI InChI=1S/C21H24N2OS/c24-20(22-19-14-5-9-23(10-6-14)21(19)7-8-21)18-12-16-4-3-15(13-1-2-13)11-17(16)25-18/h3-4,11-14,19H,1-2,5-10H2,(H,22,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Axovant Sciences GmbH US Patent					Assay Description [3H]BRL 43694 competition binding assay was performed under contract by Cerep Poitiers, France following the methods described in Hope, A. G et al., ...				US Patent US10183938 (2019) BindingDB Entry DOI: 10.7270/Q2VD71JR
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit (Homo sapiens (Human))	BDBM322298 (6-cyclopropyl-N-(1''-azaspiro[cyclopropane-1,2''-b...) Show SMILES O=C(NC1C2CCN(CC2)C11CC1)c1cc2ccc(cc2s1)C1CC1 Show InChI InChI=1S/C21H24N2OS/c24-20(22-19-14-5-9-23(10-6-14)21(19)7-8-21)18-12-16-4-3-15(13-1-2-13)11-17(16)25-18/h3-4,11-14,19H,1-2,5-10H2,(H,22,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Axovant Sciences GmbH US Patent					Assay Description The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp...				US Patent US10183938 (2019) BindingDB Entry DOI: 10.7270/Q2VD71JR
					More data for this Ligand-Target Pair