BDBM322394 3-(5-methyl-1,3-thiazol-2-yl)-5-(piperidin-3-yloxy)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10183937, Example 205::US10202369, Example 205::US10472354, Example 206
SMILES: C[C@@H](NC(=O)c1cc(OC2CCCNC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F
InChI Key: InChIKey=YIMSHVDFMHXVTO-IKJXHCRLSA-N
Data: 6 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
P2X purinoceptor 3 (Homo sapiens (Human)) | BDBM322394 (3-(5-methyl-1,3-thiazol-2-yl)-5-(piperidin-3-yloxy...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Aktiengesellschaft US Patent | Assay Description A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati... | US Patent US10183937 (2019) BindingDB Entry DOI: 10.7270/Q2028TNS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 2 (Homo sapiens (Human)) | BDBM322394 (3-(5-methyl-1,3-thiazol-2-yl)-5-(piperidin-3-yloxy...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 272 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Aktiengesellschaft US Patent | Assay Description A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati... | US Patent US10183937 (2019) BindingDB Entry DOI: 10.7270/Q2028TNS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X2/3 (Homo sapiens (Human)) | BDBM322394 (3-(5-methyl-1,3-thiazol-2-yl)-5-(piperidin-3-yloxy...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.68E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Aktiengesellschaft US Patent | Assay Description A fluorescent imaging plate reader (FILEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelat... | US Patent US10472354 (2019) BindingDB Entry DOI: 10.7270/Q2KD2197 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X2/3 (Homo sapiens (Human)) | BDBM322394 (3-(5-methyl-1,3-thiazol-2-yl)-5-(piperidin-3-yloxy...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 272 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Aktiengesellschaft US Patent | Assay Description A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati... | US Patent US10202369 (2019) BindingDB Entry DOI: 10.7270/Q2TT4T2P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 3 (Homo sapiens (Human)) | BDBM322394 (3-(5-methyl-1,3-thiazol-2-yl)-5-(piperidin-3-yloxy...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Aktiengesellschaft US Patent | Assay Description A fluorescent imaging plate reader (FILEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelat... | US Patent US10472354 (2019) BindingDB Entry DOI: 10.7270/Q2KD2197 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 3 (Homo sapiens (Human)) | BDBM322394 (3-(5-methyl-1,3-thiazol-2-yl)-5-(piperidin-3-yloxy...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Aktiengesellschaft US Patent | Assay Description A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati... | US Patent US10202369 (2019) BindingDB Entry DOI: 10.7270/Q2TT4T2P | |||||||||||
More data for this Ligand-Target Pair |