BDBM322396 3-(5-methyl-1,3-thiazol-2-yl)-5-{[2-(trifluoromethyl)piperidin-4-yl]oxy}-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10183937, Example 207::US10202369, Example 207::US10472354, Example 208

SMILES: C[C@@H](NC(=O)c1cc(OC2CCNC(C2)C(F)(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F

InChI Key: InChIKey=RLIMWYRKEDYMPQ-UYCDIGJJSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 322396   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
P2X purinoceptor 3 (Homo sapiens (Human))	BDBM322396 (3-(5-methyl-1,3-thiazol-2-yl)-5-{[2-(trifluorometh...) Show SMILES C[C@@H](NC(=O)c1cc(OC2CCNC(C2)C(F)(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F |r| Show InChI InChI=1S/C24H23F6N5O2S/c1-12-9-32-21(38-12)15-5-14(6-18(7-15)37-17-3-4-31-19(8-17)23(25,26)27)20(36)35-13(2)16-10-33-22(34-11-16)24(28,29)30/h5-7,9-11,13,17,19,31H,3-4,8H2,1-2H3,(H,35,36)/t13-,17?,19?/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Aktiengesellschaft US Patent					Assay Description A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...				US Patent US10183937 (2019) BindingDB Entry DOI: 10.7270/Q2028TNS
					More data for this Ligand-Target Pair
P2X purinoceptor 2 (Homo sapiens (Human))	BDBM322396 (3-(5-methyl-1,3-thiazol-2-yl)-5-{[2-(trifluorometh...) Show SMILES C[C@@H](NC(=O)c1cc(OC2CCNC(C2)C(F)(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F |r| Show InChI InChI=1S/C24H23F6N5O2S/c1-12-9-32-21(38-12)15-5-14(6-18(7-15)37-17-3-4-31-19(8-17)23(25,26)27)20(36)35-13(2)16-10-33-22(34-11-16)24(28,29)30/h5-7,9-11,13,17,19,31H,3-4,8H2,1-2H3,(H,35,36)/t13-,17?,19?/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	87	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Aktiengesellschaft US Patent					Assay Description A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...				US Patent US10183937 (2019) BindingDB Entry DOI: 10.7270/Q2028TNS
					More data for this Ligand-Target Pair
P2X2/3 (Homo sapiens (Human))	BDBM322396 (3-(5-methyl-1,3-thiazol-2-yl)-5-{[2-(trifluorometh...) Show SMILES C[C@@H](NC(=O)c1cc(OC2CCNC(C2)C(F)(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F |r| Show InChI InChI=1S/C24H23F6N5O2S/c1-12-9-32-21(38-12)15-5-14(6-18(7-15)37-17-3-4-31-19(8-17)23(25,26)27)20(36)35-13(2)16-10-33-22(34-11-16)24(28,29)30/h5-7,9-11,13,17,19,31H,3-4,8H2,1-2H3,(H,35,36)/t13-,17?,19?/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	89	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Aktiengesellschaft US Patent					Assay Description A fluorescent imaging plate reader (FILEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelat...				US Patent US10472354 (2019) BindingDB Entry DOI: 10.7270/Q2KD2197
					More data for this Ligand-Target Pair
P2X2/3 (Homo sapiens (Human))	BDBM322396 (3-(5-methyl-1,3-thiazol-2-yl)-5-{[2-(trifluorometh...) Show SMILES C[C@@H](NC(=O)c1cc(OC2CCNC(C2)C(F)(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F |r| Show InChI InChI=1S/C24H23F6N5O2S/c1-12-9-32-21(38-12)15-5-14(6-18(7-15)37-17-3-4-31-19(8-17)23(25,26)27)20(36)35-13(2)16-10-33-22(34-11-16)24(28,29)30/h5-7,9-11,13,17,19,31H,3-4,8H2,1-2H3,(H,35,36)/t13-,17?,19?/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	87	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Aktiengesellschaft US Patent					Assay Description A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...				US Patent US10202369 (2019) BindingDB Entry DOI: 10.7270/Q2TT4T2P
					More data for this Ligand-Target Pair
P2X purinoceptor 3 (Homo sapiens (Human))	BDBM322396 (3-(5-methyl-1,3-thiazol-2-yl)-5-{[2-(trifluorometh...) Show SMILES C[C@@H](NC(=O)c1cc(OC2CCNC(C2)C(F)(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F |r| Show InChI InChI=1S/C24H23F6N5O2S/c1-12-9-32-21(38-12)15-5-14(6-18(7-15)37-17-3-4-31-19(8-17)23(25,26)27)20(36)35-13(2)16-10-33-22(34-11-16)24(28,29)30/h5-7,9-11,13,17,19,31H,3-4,8H2,1-2H3,(H,35,36)/t13-,17?,19?/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Aktiengesellschaft US Patent					Assay Description A fluorescent imaging plate reader (FILEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelat...				US Patent US10472354 (2019) BindingDB Entry DOI: 10.7270/Q2KD2197
					More data for this Ligand-Target Pair
P2X purinoceptor 3 (Homo sapiens (Human))	BDBM322396 (3-(5-methyl-1,3-thiazol-2-yl)-5-{[2-(trifluorometh...) Show SMILES C[C@@H](NC(=O)c1cc(OC2CCNC(C2)C(F)(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F |r| Show InChI InChI=1S/C24H23F6N5O2S/c1-12-9-32-21(38-12)15-5-14(6-18(7-15)37-17-3-4-31-19(8-17)23(25,26)27)20(36)35-13(2)16-10-33-22(34-11-16)24(28,29)30/h5-7,9-11,13,17,19,31H,3-4,8H2,1-2H3,(H,35,36)/t13-,17?,19?/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Aktiengesellschaft US Patent					Assay Description A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...				US Patent US10202369 (2019) BindingDB Entry DOI: 10.7270/Q2TT4T2P
					More data for this Ligand-Target Pair