BDBM323017 1-Methyl-4-[({(1R,2R)-2-[4-(1H-pyrazol- 3-yl)benzoyl]cyclohexyl}carbonyl)amino]- 1H-pyrazole-5-carboxamide::US10183947, Example 2::US10508119, Example 2
SMILES: Cn1ncc(NC(=O)[C@@H]2CCCC[C@H]2C(=O)c2ccc(cc2)-c2cc[nH]n2)c1C(N)=O
InChI Key:
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human)) | BDBM323017 (1-Methyl-4-[({(1R,2R)-2-[4-(1H-pyrazol- 3-yl)benzo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB US Patent | Assay Description Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ... | US Patent US10183947 (2019) BindingDB Entry DOI: 10.7270/Q22Z17M7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Flap endonuclease 1 (Homo sapiens (Human)) | BDBM323017 (1-Methyl-4-[({(1R,2R)-2-[4-(1H-pyrazol- 3-yl)benzo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB US Patent | Assay Description Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ... | US Patent US11001589 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human)) | BDBM323017 (1-Methyl-4-[({(1R,2R)-2-[4-(1H-pyrazol- 3-yl)benzo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB US Patent | Assay Description Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ... | US Patent US10508119 (2019) BindingDB Entry DOI: 10.7270/Q2FB55BJ | |||||||||||
More data for this Ligand-Target Pair |