BDBM323031 (1R,2R)-N-[5-(Difluoromethyl)-1H- pyrazol-4-yl]-2-[4-(5-methyl-1H-pyrazol- 3-yl)benzoyl]cyclohexanecarboxamide::US10183947, Example 15::US10508119, Example 15
SMILES: Cc1cc(n[nH]1)-c1ccc(cc1)C(=O)[C@@H]1CCCC[C@H]1C(=O)Nc1cn[nH]c1C(F)F
InChI Key:
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Arachidonate 5-lipoxygenase (Homo sapiens (Human)) | BDBM323031 ((1R,2R)-N-[5-(Difluoromethyl)-1H- pyrazol-4-yl]-2-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 8.60 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB US Patent | Assay Description Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ... | US Patent US10183947 (2019) BindingDB Entry DOI: 10.7270/Q22Z17M7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Flap endonuclease 1 (Homo sapiens (Human)) | BDBM323031 ((1R,2R)-N-[5-(Difluoromethyl)-1H- pyrazol-4-yl]-2-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 8.60 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB US Patent | Assay Description Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ... | US Patent US11001589 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-lipoxygenase/FLAP (Homo sapiens (Human)) | BDBM323031 ((1R,2R)-N-[5-(Difluoromethyl)-1H- pyrazol-4-yl]-2-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 8.60 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB US Patent | Assay Description Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ... | US Patent US10508119 (2019) BindingDB Entry DOI: 10.7270/Q2FB55BJ | |||||||||||
More data for this Ligand-Target Pair |