BDBM323045 (1R,2R)-N-(2-Methyl-4-oxo-4,5,6,7- tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-2- [4-(5-methyl-1H-pyrazol-3- yl)benzoyl]cyclohexanecarboxamide::US10183947, Example 28::US10508119, Example 28::US11001589, Example 28
SMILES: Cc1cc(n[nH]1)-c1ccc(cc1)C(=O)[C@@H]1CCCC[C@H]1C(=O)Nc1c(C)nn2CCNC(=O)c12
InChI Key:
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human)) | BDBM323045 ((1R,2R)-N-(2-Methyl-4-oxo-4,5,6,7- tetrahydropyraz...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB US Patent | Assay Description Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ... | US Patent US10183947 (2019) BindingDB Entry DOI: 10.7270/Q22Z17M7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Flap endonuclease 1 (Homo sapiens (Human)) | BDBM323045 ((1R,2R)-N-(2-Methyl-4-oxo-4,5,6,7- tetrahydropyraz...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB US Patent | Assay Description Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ... | US Patent US11001589 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human)) | BDBM323045 ((1R,2R)-N-(2-Methyl-4-oxo-4,5,6,7- tetrahydropyraz...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB US Patent | Assay Description Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ... | US Patent US10508119 (2019) BindingDB Entry DOI: 10.7270/Q2FB55BJ | |||||||||||
More data for this Ligand-Target Pair |