BDBM323113 4-((trans-4-(3,4-dichlorophenyl)piperidin-3-yl)methoxy)-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide::US9630929, Example 92

SMILES: Fc1cc(c(F)cc1OC[C@@H]1CNCCC1c1ccc(Cl)c(Cl)c1)S(=O)(=O)Nc1ncns1

InChI Key: InChIKey=JVNFXYUGRQQZML-UEWDXFNNSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 323113   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM323113 (4-((trans-4-(3,4-dichlorophenyl)piperidin-3-yl)met...) Show SMILES Fc1cc(c(F)cc1OC[C@@H]1CNCCC1c1ccc(Cl)c(Cl)c1)S(=O)(=O)Nc1ncns1 |r| Show InChI InChI=1S/C20H18Cl2F2N4O3S2/c21-14-2-1-11(5-15(14)22)13-3-4-25-8-12(13)9-31-18-6-17(24)19(7-16(18)23)33(29,30)28-20-26-10-27-32-20/h1-2,5-7,10,12-13,25H,3-4,8-9H2,(H,26,27,28)/t12-,13?/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9630929 (2017) BindingDB Entry DOI: 10.7270/Q2F47R7X
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM323113 (4-((trans-4-(3,4-dichlorophenyl)piperidin-3-yl)met...) Show SMILES Fc1cc(c(F)cc1OC[C@@H]1CNCCC1c1ccc(Cl)c(Cl)c1)S(=O)(=O)Nc1ncns1 |r| Show InChI InChI=1S/C20H18Cl2F2N4O3S2/c21-14-2-1-11(5-15(14)22)13-3-4-25-8-12(13)9-31-18-6-17(24)19(7-16(18)23)33(29,30)28-20-26-10-27-32-20/h1-2,5-7,10,12-13,25H,3-4,8-9H2,(H,26,27,28)/t12-,13?/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9630929 (2017) BindingDB Entry DOI: 10.7270/Q2F47R7X
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM323113 (4-((trans-4-(3,4-dichlorophenyl)piperidin-3-yl)met...) Show SMILES Fc1cc(c(F)cc1OC[C@@H]1CNCCC1c1ccc(Cl)c(Cl)c1)S(=O)(=O)Nc1ncns1 |r| Show InChI InChI=1S/C20H18Cl2F2N4O3S2/c21-14-2-1-11(5-15(14)22)13-3-4-25-8-12(13)9-31-18-6-17(24)19(7-16(18)23)33(29,30)28-20-26-10-27-32-20/h1-2,5-7,10,12-13,25H,3-4,8-9H2,(H,26,27,28)/t12-,13?/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9630929 (2017) BindingDB Entry DOI: 10.7270/Q2F47R7X
					More data for this Ligand-Target Pair