BDBM324211 US10189819, Example 48::US10189819, Example 54

SMILES: COc1cc2nc([nH]c2cc1Cl)C(CNC(=O)c1c(Cl)cc(cc1Cl)-n1cnc(C)n1)c1cccc(F)c1

InChI Key:

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 324211   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Coagulation factor IX (Homo sapiens (Human))	BDBM324211 (US10189819, Example 48 | US10189819, Example 54) Show SMILES COc1cc2nc([nH]c2cc1Cl)C(CNC(=O)c1c(Cl)cc(cc1Cl)-n1cnc(C)n1)c1cccc(F)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.86	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme, Corp.; Mochida Paraceuticals Co., Ltd. US Patent					Assay Description Formation of a clot to stem bleeding at a site of blood vessel injury involves the coordinated activity of a group of plasma proteins that initiate a...				US Patent US10189819 (2019) BindingDB Entry DOI: 10.7270/Q200046Z
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM324211 (US10189819, Example 48 | US10189819, Example 54) Show SMILES COc1cc2nc([nH]c2cc1Cl)C(CNC(=O)c1c(Cl)cc(cc1Cl)-n1cnc(C)n1)c1cccc(F)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.86	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme, Corp.; Mochida Paraceuticals Co., Ltd. US Patent					Assay Description Formation of a clot to stem bleeding at a site of blood vessel injury involves the coordinated activity of a group of plasma proteins that initiate a...				US Patent US10189819 (2019) BindingDB Entry DOI: 10.7270/Q200046Z
					More data for this Ligand-Target Pair