BDBM324610 2-[4-[[8-[8-(3,3- difluoroazetidine-1- carbonyl)-3,8- diazabicyclo[3.2.1]octan- 3-yl]-[1,2,4]triazolo[1,5-a] pyridin-2- yl]amino]pyrazol-1-yl]-1- (4-methylpiperazin-1- yl)ethanone::US10189836, Example 173

SMILES: CN1CCN(CC1)C(=O)Cn1cc(Nc2nc3c(cccn3n2)N2CC3CCC(C2)N3C(=O)N2CC(F)(F)C2)cn1

InChI Key: InChIKey=XVEGZOZIYUNCBU-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 324610   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM324610 (2-[4-[[8-[8-(3,3- difluoroazetidine-1- carbonyl)-3...) Show SMILES CN1CCN(CC1)C(=O)Cn1cc(Nc2nc3c(cccn3n2)N2CC3CCC(C2)N3C(=O)N2CC(F)(F)C2)cn1 Show InChI InChI=1S/C26H33F2N11O2/c1-33-7-9-34(10-8-33)22(40)15-37-12-18(11-29-37)30-24-31-23-21(3-2-6-38(23)32-24)35-13-19-4-5-20(14-35)39(19)25(41)36-16-26(27,28)17-36/h2-3,6,11-12,19-20H,4-5,7-10,13-17H2,1H3,(H,30,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US10189836 (2019) BindingDB Entry DOI: 10.7270/Q2G162XH
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM324610 (2-[4-[[8-[8-(3,3- difluoroazetidine-1- carbonyl)-3...) Show SMILES CN1CCN(CC1)C(=O)Cn1cc(Nc2nc3c(cccn3n2)N2CC3CCC(C2)N3C(=O)N2CC(F)(F)C2)cn1 Show InChI InChI=1S/C26H33F2N11O2/c1-33-7-9-34(10-8-33)22(40)15-37-12-18(11-29-37)30-24-31-23-21(3-2-6-38(23)32-24)35-13-19-4-5-20(14-35)39(19)25(41)36-16-26(27,28)17-36/h2-3,6,11-12,19-20H,4-5,7-10,13-17H2,1H3,(H,30,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US10189836 (2019) BindingDB Entry DOI: 10.7270/Q2G162XH
					More data for this Ligand-Target Pair