BDBM324632 1-(4-methylpiperazin-1- yl)-2-[4-[[8-[rac-(1S,5R)- 8-[[3- (hydroxymethyl)phenyl] methoxy]-3- azabicyclo[3.2.1]octan-3- yl]-[1,2,4]triazolo[1,5-a] pyridin-2- yl]amino]pyrazol-1- yl]ethanone::US10189836, Example 195

SMILES: CN1CCN(CC1)C(=O)Cn1cc(Nc2nc3c(cccn3n2)N2C[C@@H]3CC[C@H](C2)[C@@H]3OCc2cccc(CO)c2)cn1

InChI Key: InChIKey=CXJIEFKRERYCMA-ZQBGQUGVSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 324632   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM324632 (1-(4-methylpiperazin-1- yl)-2-[4-[[8-[rac-(1S,5R)-...) Show SMILES CN1CCN(CC1)C(=O)Cn1cc(Nc2nc3c(cccn3n2)N2C[C@@H]3CC[C@H](C2)[C@@H]3OCc2cccc(CO)c2)cn1 |r| Show InChI InChI=1S/C31H39N9O3/c1-36-10-12-37(13-11-36)28(42)19-39-18-26(15-32-39)33-31-34-30-27(6-3-9-40(30)35-31)38-16-24-7-8-25(17-38)29(24)43-21-23-5-2-4-22(14-23)20-41/h2-6,9,14-15,18,24-25,29,41H,7-8,10-13,16-17,19-21H2,1H3,(H,33,35)/t24-,25+,29+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US10189836 (2019) BindingDB Entry DOI: 10.7270/Q2G162XH
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM324632 (1-(4-methylpiperazin-1- yl)-2-[4-[[8-[rac-(1S,5R)-...) Show SMILES CN1CCN(CC1)C(=O)Cn1cc(Nc2nc3c(cccn3n2)N2C[C@@H]3CC[C@H](C2)[C@@H]3OCc2cccc(CO)c2)cn1 |r| Show InChI InChI=1S/C31H39N9O3/c1-36-10-12-37(13-11-36)28(42)19-39-18-26(15-32-39)33-31-34-30-27(6-3-9-40(30)35-31)38-16-24-7-8-25(17-38)29(24)43-21-23-5-2-4-22(14-23)20-41/h2-6,9,14-15,18,24-25,29,41H,7-8,10-13,16-17,19-21H2,1H3,(H,33,35)/t24-,25+,29+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.700	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US10189836 (2019) BindingDB Entry DOI: 10.7270/Q2G162XH
					More data for this Ligand-Target Pair