BDBM325048 2-(4-(4-((2-(2-isopropylphenyl)-8-oxo-7,8-dihydro-9H-::US10189841, Compound I-254::US10399980, Compound I-254

SMILES: CC(C)c1ccccc1-c1ncc2[nH]c(=O)n(Cc3ccc(cc3)-c3cnn(C)c3CC(O)=O)c2n1

InChI Key: InChIKey=LUCFOBLOYFGXOD-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 325048   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ubiquitin carboxyl-terminal hydrolase 1 (Homo sapiens (Human))	BDBM325048 (2-(4-(4-((2-(2-isopropylphenyl)-8-oxo-7,8-dihydro-...) Show SMILES CC(C)c1ccccc1-c1ncc2[nH]c(=O)n(Cc3ccc(cc3)-c3cnn(C)c3CC(O)=O)c2n1 Show InChI InChI=1S/C27H26N6O3/c1-16(2)19-6-4-5-7-20(19)25-28-14-22-26(31-25)33(27(36)30-22)15-17-8-10-18(11-9-17)21-13-29-32(3)23(21)12-24(34)35/h4-11,13-14,16H,12,15H2,1-3H3,(H,30,36)(H,34,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
FORMA Therapeutics, Inc. US Patent					Assay Description The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...				US Patent US10399980 (2019) BindingDB Entry DOI: 10.7270/Q23J3GCX
					More data for this Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1 (Homo sapiens (Human))	BDBM325048 (2-(4-(4-((2-(2-isopropylphenyl)-8-oxo-7,8-dihydro-...) Show SMILES CC(C)c1ccccc1-c1ncc2[nH]c(=O)n(Cc3ccc(cc3)-c3cnn(C)c3CC(O)=O)c2n1 Show InChI InChI=1S/C27H26N6O3/c1-16(2)19-6-4-5-7-20(19)25-28-14-22-26(31-25)33(27(36)30-22)15-17-8-10-18(11-9-17)21-13-29-32(3)23(21)12-24(34)35/h4-11,13-14,16H,12,15H2,1-3H3,(H,30,36)(H,34,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.00200	n/a	n/a	n/a	n/a	n/a	n/a
FORMA Therapeutics, Inc. US Patent					Assay Description The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...				US Patent US10189841 (2019) BindingDB Entry DOI: 10.7270/Q22R3TRR
					More data for this Ligand-Target Pair