BDBM325385 3-(4-(6-(1-methyl-1H- pyrazol-4- yl)pyrazolo[1,5- a]pyrazin-4-yl)-1H- pyrazol-1-yl)pentan-1-ol::US10189845, Example 47::US10730880, Example 47

SMILES: CCC(CCO)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C)c1

InChI Key: InChIKey=PBBVBJNUBYULHP-UHFFFAOYSA-N

Data: 12 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 325385   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM325385 (3-(4-(6-(1-methyl-1H- pyrazol-4- yl)pyrazolo[1,5- ...) Show SMILES CCC(CCO)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C)c1 Show InChI InChI=1S/C18H21N7O/c1-3-15(5-7-26)24-11-14(9-21-24)18-17-4-6-19-25(17)12-16(22-18)13-8-20-23(2)10-13/h4,6,8-12,15,26H,3,5,7H2,1-2H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US10189845 (2019) BindingDB Entry DOI: 10.7270/Q2Z03B7Q
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM325385 (3-(4-(6-(1-methyl-1H- pyrazol-4- yl)pyrazolo[1,5- ...) Show SMILES CCC(CCO)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C)c1 Show InChI InChI=1S/C18H21N7O/c1-3-15(5-7-26)24-11-14(9-21-24)18-17-4-6-19-25(17)12-16(22-18)13-8-20-23(2)10-13/h4,6,8-12,15,26H,3,5,7H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit JAK1 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US10189845 (2019) BindingDB Entry DOI: 10.7270/Q2Z03B7Q
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM325385 (3-(4-(6-(1-methyl-1H- pyrazol-4- yl)pyrazolo[1,5- ...) Show SMILES CCC(CCO)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C)c1 Show InChI InChI=1S/C18H21N7O/c1-3-15(5-7-26)24-11-14(9-21-24)18-17-4-6-19-25(17)12-16(22-18)13-8-20-23(2)10-13/h4,6,8-12,15,26H,3,5,7H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US10189845 (2019) BindingDB Entry DOI: 10.7270/Q2Z03B7Q
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM325385 (3-(4-(6-(1-methyl-1H- pyrazol-4- yl)pyrazolo[1,5- ...) Show SMILES CCC(CCO)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C)c1 Show InChI InChI=1S/C18H21N7O/c1-3-15(5-7-26)24-11-14(9-21-24)18-17-4-6-19-25(17)12-16(22-18)13-8-20-23(2)10-13/h4,6,8-12,15,26H,3,5,7H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit JAK3 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US10189845 (2019) BindingDB Entry DOI: 10.7270/Q2Z03B7Q
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM325385 (3-(4-(6-(1-methyl-1H- pyrazol-4- yl)pyrazolo[1,5- ...) Show SMILES CCC(CCO)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C)c1 Show InChI InChI=1S/C18H21N7O/c1-3-15(5-7-26)24-11-14(9-21-24)18-17-4-6-19-25(17)12-16(22-18)13-8-20-23(2)10-13/h4,6,8-12,15,26H,3,5,7H2,1-2H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc.; Celgene Corporation US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US10730880 (2020)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM325385 (3-(4-(6-(1-methyl-1H- pyrazol-4- yl)pyrazolo[1,5- ...) Show SMILES CCC(CCO)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C)c1 Show InChI InChI=1S/C18H21N7O/c1-3-15(5-7-26)24-11-14(9-21-24)18-17-4-6-19-25(17)12-16(22-18)13-8-20-23(2)10-13/h4,6,8-12,15,26H,3,5,7H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARRAY BIOPHARMA INC.; CELGENE CORPORATION US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit JAK3 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US11028093 (2021)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM325385 (3-(4-(6-(1-methyl-1H- pyrazol-4- yl)pyrazolo[1,5- ...) Show SMILES CCC(CCO)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C)c1 Show InChI InChI=1S/C18H21N7O/c1-3-15(5-7-26)24-11-14(9-21-24)18-17-4-6-19-25(17)12-16(22-18)13-8-20-23(2)10-13/h4,6,8-12,15,26H,3,5,7H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc.; Celgene Corporation US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US10730880 (2020)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM325385 (3-(4-(6-(1-methyl-1H- pyrazol-4- yl)pyrazolo[1,5- ...) Show SMILES CCC(CCO)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C)c1 Show InChI InChI=1S/C18H21N7O/c1-3-15(5-7-26)24-11-14(9-21-24)18-17-4-6-19-25(17)12-16(22-18)13-8-20-23(2)10-13/h4,6,8-12,15,26H,3,5,7H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc.; Celgene Corporation US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit JAK3 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US10730880 (2020)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM325385 (3-(4-(6-(1-methyl-1H- pyrazol-4- yl)pyrazolo[1,5- ...) Show SMILES CCC(CCO)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C)c1 Show InChI InChI=1S/C18H21N7O/c1-3-15(5-7-26)24-11-14(9-21-24)18-17-4-6-19-25(17)12-16(22-18)13-8-20-23(2)10-13/h4,6,8-12,15,26H,3,5,7H2,1-2H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARRAY BIOPHARMA INC.; CELGENE CORPORATION US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US11028093 (2021)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM325385 (3-(4-(6-(1-methyl-1H- pyrazol-4- yl)pyrazolo[1,5- ...) Show SMILES CCC(CCO)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C)c1 Show InChI InChI=1S/C18H21N7O/c1-3-15(5-7-26)24-11-14(9-21-24)18-17-4-6-19-25(17)12-16(22-18)13-8-20-23(2)10-13/h4,6,8-12,15,26H,3,5,7H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARRAY BIOPHARMA INC.; CELGENE CORPORATION US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit JAK1 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US11028093 (2021)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM325385 (3-(4-(6-(1-methyl-1H- pyrazol-4- yl)pyrazolo[1,5- ...) Show SMILES CCC(CCO)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C)c1 Show InChI InChI=1S/C18H21N7O/c1-3-15(5-7-26)24-11-14(9-21-24)18-17-4-6-19-25(17)12-16(22-18)13-8-20-23(2)10-13/h4,6,8-12,15,26H,3,5,7H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARRAY BIOPHARMA INC.; CELGENE CORPORATION US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US11028093 (2021)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM325385 (3-(4-(6-(1-methyl-1H- pyrazol-4- yl)pyrazolo[1,5- ...) Show SMILES CCC(CCO)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C)c1 Show InChI InChI=1S/C18H21N7O/c1-3-15(5-7-26)24-11-14(9-21-24)18-17-4-6-19-25(17)12-16(22-18)13-8-20-23(2)10-13/h4,6,8-12,15,26H,3,5,7H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc.; Celgene Corporation US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit JAK1 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US10730880 (2020)
					More data for this Ligand-Target Pair