null

SMILES: CC[C@H](O)Cn1cc(cn1)-c1cn2nccc2c(n1)-c1cnn(c1)C(CC)CC

InChI Key: InChIKey=AMTYSNROYXSBLL-SFHVURJKSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 325452   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM325452 ((S)-1-(4-(4-(1-(pentan-3- yl)-1H-pyrazol-4- yl)pyr...) Show SMILES CC[C@H](O)Cn1cc(cn1)-c1cn2nccc2c(n1)-c1cnn(c1)C(CC)CC |r| Show InChI InChI=1S/C21H27N7O/c1-4-17(5-2)27-12-16(10-24-27)21-20-7-8-22-28(20)14-19(25-21)15-9-23-26(11-15)13-18(29)6-3/h7-12,14,17-18,29H,4-6,13H2,1-3H3/t18-/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US10189845 (2019) BindingDB Entry DOI: 10.7270/Q2Z03B7Q
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM325452 ((S)-1-(4-(4-(1-(pentan-3- yl)-1H-pyrazol-4- yl)pyr...) Show SMILES CC[C@H](O)Cn1cc(cn1)-c1cn2nccc2c(n1)-c1cnn(c1)C(CC)CC |r| Show InChI InChI=1S/C21H27N7O/c1-4-17(5-2)27-12-16(10-24-27)21-20-7-8-22-28(20)14-19(25-21)15-9-23-26(11-15)13-18(29)6-3/h7-12,14,17-18,29H,4-6,13H2,1-3H3/t18-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit JAK1 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US10189845 (2019) BindingDB Entry DOI: 10.7270/Q2Z03B7Q
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM325452 ((S)-1-(4-(4-(1-(pentan-3- yl)-1H-pyrazol-4- yl)pyr...) Show SMILES CC[C@H](O)Cn1cc(cn1)-c1cn2nccc2c(n1)-c1cnn(c1)C(CC)CC |r| Show InChI InChI=1S/C21H27N7O/c1-4-17(5-2)27-12-16(10-24-27)21-20-7-8-22-28(20)14-19(25-21)15-9-23-26(11-15)13-18(29)6-3/h7-12,14,17-18,29H,4-6,13H2,1-3H3/t18-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US10189845 (2019) BindingDB Entry DOI: 10.7270/Q2Z03B7Q
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM325452 ((S)-1-(4-(4-(1-(pentan-3- yl)-1H-pyrazol-4- yl)pyr...) Show SMILES CC[C@H](O)Cn1cc(cn1)-c1cn2nccc2c(n1)-c1cnn(c1)C(CC)CC |r| Show InChI InChI=1S/C21H27N7O/c1-4-17(5-2)27-12-16(10-24-27)21-20-7-8-22-28(20)14-19(25-21)15-9-23-26(11-15)13-18(29)6-3/h7-12,14,17-18,29H,4-6,13H2,1-3H3/t18-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit JAK3 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US10189845 (2019) BindingDB Entry DOI: 10.7270/Q2Z03B7Q
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM325452 ((S)-1-(4-(4-(1-(pentan-3- yl)-1H-pyrazol-4- yl)pyr...) Show SMILES CC[C@H](O)Cn1cc(cn1)-c1cn2nccc2c(n1)-c1cnn(c1)C(CC)CC |r| Show InChI InChI=1S/C21H27N7O/c1-4-17(5-2)27-12-16(10-24-27)21-20-7-8-22-28(20)14-19(25-21)15-9-23-26(11-15)13-18(29)6-3/h7-12,14,17-18,29H,4-6,13H2,1-3H3/t18-/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc.; Celgene Corporation US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US10730880 (2020) BindingDB Entry DOI: 10.7270/Q2CC13R9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM325452 ((S)-1-(4-(4-(1-(pentan-3- yl)-1H-pyrazol-4- yl)pyr...) Show SMILES CC[C@H](O)Cn1cc(cn1)-c1cn2nccc2c(n1)-c1cnn(c1)C(CC)CC |r| Show InChI InChI=1S/C21H27N7O/c1-4-17(5-2)27-12-16(10-24-27)21-20-7-8-22-28(20)14-19(25-21)15-9-23-26(11-15)13-18(29)6-3/h7-12,14,17-18,29H,4-6,13H2,1-3H3/t18-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARRAY BIOPHARMA INC.; CELGENE CORPORATION US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit JAK3 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US11028093 (2021) BindingDB Entry DOI: 10.7270/Q2T156RN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM325452 ((S)-1-(4-(4-(1-(pentan-3- yl)-1H-pyrazol-4- yl)pyr...) Show SMILES CC[C@H](O)Cn1cc(cn1)-c1cn2nccc2c(n1)-c1cnn(c1)C(CC)CC |r| Show InChI InChI=1S/C21H27N7O/c1-4-17(5-2)27-12-16(10-24-27)21-20-7-8-22-28(20)14-19(25-21)15-9-23-26(11-15)13-18(29)6-3/h7-12,14,17-18,29H,4-6,13H2,1-3H3/t18-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc.; Celgene Corporation US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US10730880 (2020) BindingDB Entry DOI: 10.7270/Q2CC13R9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM325452 ((S)-1-(4-(4-(1-(pentan-3- yl)-1H-pyrazol-4- yl)pyr...) Show SMILES CC[C@H](O)Cn1cc(cn1)-c1cn2nccc2c(n1)-c1cnn(c1)C(CC)CC |r| Show InChI InChI=1S/C21H27N7O/c1-4-17(5-2)27-12-16(10-24-27)21-20-7-8-22-28(20)14-19(25-21)15-9-23-26(11-15)13-18(29)6-3/h7-12,14,17-18,29H,4-6,13H2,1-3H3/t18-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc.; Celgene Corporation US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit JAK3 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US10730880 (2020) BindingDB Entry DOI: 10.7270/Q2CC13R9
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM325452 ((S)-1-(4-(4-(1-(pentan-3- yl)-1H-pyrazol-4- yl)pyr...) Show SMILES CC[C@H](O)Cn1cc(cn1)-c1cn2nccc2c(n1)-c1cnn(c1)C(CC)CC |r| Show InChI InChI=1S/C21H27N7O/c1-4-17(5-2)27-12-16(10-24-27)21-20-7-8-22-28(20)14-19(25-21)15-9-23-26(11-15)13-18(29)6-3/h7-12,14,17-18,29H,4-6,13H2,1-3H3/t18-/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
ARRAY BIOPHARMA INC.; CELGENE CORPORATION US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US11028093 (2021) BindingDB Entry DOI: 10.7270/Q2T156RN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM325452 ((S)-1-(4-(4-(1-(pentan-3- yl)-1H-pyrazol-4- yl)pyr...) Show SMILES CC[C@H](O)Cn1cc(cn1)-c1cn2nccc2c(n1)-c1cnn(c1)C(CC)CC |r| Show InChI InChI=1S/C21H27N7O/c1-4-17(5-2)27-12-16(10-24-27)21-20-7-8-22-28(20)14-19(25-21)15-9-23-26(11-15)13-18(29)6-3/h7-12,14,17-18,29H,4-6,13H2,1-3H3/t18-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
ARRAY BIOPHARMA INC.; CELGENE CORPORATION US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit JAK1 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US11028093 (2021) BindingDB Entry DOI: 10.7270/Q2T156RN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM325452 ((S)-1-(4-(4-(1-(pentan-3- yl)-1H-pyrazol-4- yl)pyr...) Show SMILES CC[C@H](O)Cn1cc(cn1)-c1cn2nccc2c(n1)-c1cnn(c1)C(CC)CC |r| Show InChI InChI=1S/C21H27N7O/c1-4-17(5-2)27-12-16(10-24-27)21-20-7-8-22-28(20)14-19(25-21)15-9-23-26(11-15)13-18(29)6-3/h7-12,14,17-18,29H,4-6,13H2,1-3H3/t18-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
ARRAY BIOPHARMA INC.; CELGENE CORPORATION US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US11028093 (2021) BindingDB Entry DOI: 10.7270/Q2T156RN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM325452 ((S)-1-(4-(4-(1-(pentan-3- yl)-1H-pyrazol-4- yl)pyr...) Show SMILES CC[C@H](O)Cn1cc(cn1)-c1cn2nccc2c(n1)-c1cnn(c1)C(CC)CC |r| Show InChI InChI=1S/C21H27N7O/c1-4-17(5-2)27-12-16(10-24-27)21-20-7-8-22-28(20)14-19(25-21)15-9-23-26(11-15)13-18(29)6-3/h7-12,14,17-18,29H,4-6,13H2,1-3H3/t18-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc.; Celgene Corporation US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit JAK1 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US10730880 (2020) BindingDB Entry DOI: 10.7270/Q2CC13R9
					More data for this Ligand-Target Pair