BDBM326252 4-amino-6-(2-(7-fluoro-2-morpholinoquinolin-3-yl)pyrrolidin-1-yl)pyrimidine-5-carbonitrile::US9637488, 7

SMILES: Nc1ncnc(N2CCCC2c2cc3ccc(F)cc3nc2N2CCOCC2)c1C#N

InChI Key: InChIKey=CNNVISSMGRRJFB-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 326252   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM326252 (4-amino-6-(2-(7-fluoro-2-morpholinoquinolin-3-yl)p...) Show SMILES Nc1ncnc(N2CCCC2c2cc3ccc(F)cc3nc2N2CCOCC2)c1C#N Show InChI InChI=1S/C22H22FN7O/c23-15-4-3-14-10-16(22(28-18(14)11-15)29-6-8-31-9-7-29)19-2-1-5-30(19)21-17(12-24)20(25)26-13-27-21/h3-4,10-11,13,19H,1-2,5-9H2,(H2,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...				US Patent US9637488 (2017) BindingDB Entry DOI: 10.7270/Q2D220Q6
					More data for this Ligand-Target Pair