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SMILES: Cc1cccc2cc([C@H]3CCCN3c3ncnc4nc[nH]c34)c(nc12)N1CCOCC1

InChI Key: InChIKey=UNKKAFJMKUWSQN-GOSISDBHSA-N

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 326281   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))		BDBM326281
PNG
(US9637488, 64)
Show SMILES Cc1cccc2cc([C@H]3CCCN3c3ncnc4nc[nH]c34)c(nc12)N1CCOCC1
Show InChI InChI=1S/C23H25N7O/c1-15-4-2-5-16-12-17(22(28-19(15)16)29-8-10-31-11-9-29)18-6-3-7-30(18)23-20-21(25-13-24-20)26-14-27-23/h2,4-5,12-14,18H,3,6-11H2,1H3,(H,24,25,26,27)/t18-/m1/s1
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PC cid
PC sid
UniChem
US Patent
n/an/a 1.60n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...

US Patent US9637488 (2017)


BindingDB Entry DOI: 10.7270/Q2D220Q6
More data for this
Ligand-Target Pair