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SMILES: Nc1ncnc(N2CCC[C@@H]2c2cc3cccc(Cl)c3nc2N2CCOCC2)c1C#N

InChI Key: InChIKey=PDCWNBQZVBVDAY-GOSISDBHSA-N

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   Substructure
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 326286   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))		BDBM326286
PNG
(US9637488, 69)
Show SMILES Nc1ncnc(N2CCC[C@@H]2c2cc3cccc(Cl)c3nc2N2CCOCC2)c1C#N
Show InChI InChI=1S/C22H22ClN7O/c23-17-4-1-3-14-11-15(22(28-19(14)17)29-7-9-31-10-8-29)18-5-2-6-30(18)21-16(12-24)20(25)26-13-27-21/h1,3-4,11,13,18H,2,5-10H2,(H2,25,26,27)/t18-/m1/s1
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US Patent
n/an/a<0.0500n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...

US Patent US9637488 (2017)


BindingDB Entry DOI: 10.7270/Q2D220Q6
More data for this
Ligand-Target Pair