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SMILES: COCCCc1cnc(Nc2cnc(cn2)C#N)cc1NC[C@H]1CNCCO1

InChI Key: InChIKey=UKFMFQUZEVBPRN-MRXNPFEDSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 329009   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM329009
PNG
(1137478-54-6 | US9663503, Compound Y-159)
Show SMILES COCCCc1cnc(Nc2cnc(cn2)C#N)cc1NC[C@H]1CNCCO1 |r|
Show InChI InChI=1S/C19H25N7O2/c1-27-5-2-3-14-9-24-18(26-19-13-22-15(8-20)10-25-19)7-17(14)23-12-16-11-21-4-6-28-16/h7,9-10,13,16,21H,2-6,11-12H2,1H3,(H2,23,24,25,26)/t16-/m1/s1
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n/an/a 23n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
CHK1 kinase activity was measured in a microfluidic assay that monitors the separation of a phosphorylated product from its substrate. The assay was ...

US Patent US9663503 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W7G
More data for this
Ligand-Target Pair