BDBM329540 2-((1S,2S)-2-((2-methyl- 5-(2-methylpyridin-4- yl)pyrimidin-4- yloxy)methyl)cyclopropyl) quinoline::US9663513, 153

SMILES: Cc1cc(ccn1)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc2ccccc2n1

InChI Key: InChIKey=OKHAUSZHQHCLEU-UXHICEINSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 329540   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM329540 (2-((1S,2S)-2-((2-methyl- 5-(2-methylpyridin-4- yl)...) Show SMILES Cc1cc(ccn1)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc2ccccc2n1 |r| Show InChI InChI=1S/C24H22N4O/c1-15-11-18(9-10-25-15)21-13-26-16(2)27-24(21)29-14-19-12-20(19)23-8-7-17-5-3-4-6-22(17)28-23/h3-11,13,19-20H,12,14H2,1-2H3/t19-,20+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...				US Patent US9663513 (2017) BindingDB Entry DOI: 10.7270/Q25D8TXC
					More data for this Ligand-Target Pair