BDBM329899 (s.e.)-((1R,2R,3S,4R)-4-(2-(4-(dimethylamino)naphthalen-1-yl)pyrazolo[1,5-::US10202389, Compound I-107::US9663525, Compound I-107

SMILES: CN(C)c1ccc(-c2cc3nccc(N[C@@H]4C[C@H](COS(N)(=O)=O)[C@@H](O)[C@H]4O)n3n2)c2ccccc12

InChI Key: InChIKey=DWYLUBMPXHUNEX-FSICJWCISA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 329899   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ubiquitin-like modifier-activating enzyme 1 (Homo sapiens (Human))	BDBM329899 ((s.e.)-((1R,2R,3S,4R)-4-(2-(4-(dimethylamino)napht...) Show SMILES CN(C)c1ccc(-c2cc3nccc(N[C@@H]4C[C@H](COS(N)(=O)=O)[C@@H](O)[C@H]4O)n3n2)c2ccccc12 |r| Show InChI InChI=1S/C24H28N6O5S/c1-29(2)20-8-7-16(15-5-3-4-6-17(15)20)18-12-22-26-10-9-21(30(22)28-18)27-19-11-14(23(31)24(19)32)13-35-36(25,33)34/h3-10,12,14,19,23-24,27,31-32H,11,13H2,1-2H3,(H2,25,33,34)/t14-,19-,23-,24+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals, Inc. US Patent					Assay Description The UAE enzymatic reaction totals 50 μL and contains 50 mmol HEPES (pH 7.5), 0.05% BSA, 2.5 mM MgCl2, 0.1 uM ATP, 8 nM GST-Ubc-2, 35 nM flag-ubi...				US Patent US10202389 (2019) BindingDB Entry DOI: 10.7270/Q2DN475J
					More data for this Ligand-Target Pair
E2 ubiquitin-conjugating enzyme E1 (Homo sapiens (Human))	BDBM329899 ((s.e.)-((1R,2R,3S,4R)-4-(2-(4-(dimethylamino)napht...) Show SMILES CN(C)c1ccc(-c2cc3nccc(N[C@@H]4C[C@H](COS(N)(=O)=O)[C@@H](O)[C@H]4O)n3n2)c2ccccc12 |r| Show InChI InChI=1S/C24H28N6O5S/c1-29(2)20-8-7-16(15-5-3-4-6-17(15)20)18-12-22-26-10-9-21(30(22)28-18)27-19-11-14(23(31)24(19)32)13-35-36(25,33)34/h3-10,12,14,19,23-24,27,31-32H,11,13H2,1-2H3,(H2,25,33,34)/t14-,19-,23-,24+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals, Inc. US Patent					Assay Description The UAE enzymatic reaction totals 50 μL and contains 50 mmol HEPES (pH 7.5), 0.05% BSA, 2.5 mM MgCl2, 0.1 uM ATP, 8 nM GST-Ubc-2, 35 nM flag-ubi...				US Patent US9663525 (2017) BindingDB Entry DOI: 10.7270/Q2HM5BJP
					More data for this Ligand-Target Pair