BDBM330391 US9725436, Entry 10
SMILES: Clc1cc(\C=C\c2ccc(cc2)N2CCN(CC2)C2=NCCO2)cc(c1)-c1ccncc1
InChI Key: InChIKey=NGGFYUPEXGIRCT-OWOJBTEDSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cytochrome P450-C17 (CYP17A1) (Bos taurus (Bovine)) | BDBM330391 (US9725436, Entry 10) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
CORTENDO AB (PUBL) US Patent | Assay Description Cyp17 assay protocol: AD293 cells that stably over-express recombinant CYP-17 were seeded in 96 well plates coated with poly D-lysine (15,000 cell pe... | US Patent US9725436 (2017) BindingDB Entry DOI: 10.7270/Q2KD211N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 17A1 (Homo sapiens (Human)) | BDBM330391 (US9725436, Entry 10) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Temple University School of Pharmacy Curated by ChEMBL | Assay Description Inhibition of recombinant CYP17 (unknown origin) expressed in human AD293 cells using [21-3H]17alpha-hydroxypregnenolone as substrate preincubated fo... | Bioorg Med Chem Lett 28: 2270-2274 (2018) Article DOI: 10.1016/j.bmcl.2018.05.040 BindingDB Entry DOI: 10.7270/Q2RJ4N0B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450-C17 (CYP17A1) (Bos taurus (Bovine)) | BDBM330391 (US9725436, Entry 10) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
CORTENDO AB (PUBL) US Patent | Assay Description Cyp21 assay protocol: AD293 cells that stably over-express recombinant CYP-21 were seeded in 96 well plates coated with poly D-lysine (10,000 cell pe... | US Patent US9725436 (2017) BindingDB Entry DOI: 10.7270/Q2KD211N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 11A1 (CYP11A1) (Bos taurus (Bovine)) | BDBM330391 (US9725436, Entry 10) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
CORTENDO AB (PUBL) US Patent | Assay Description Cyp11 assay protocol: AD293 cells that stably over-express recombinant CYP-11 were seeded in 96 well plates coated with poly D-lysine (15,000 cell pe... | US Patent US9725436 (2017) BindingDB Entry DOI: 10.7270/Q2KD211N | |||||||||||
More data for this Ligand-Target Pair |