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SMILES: COc1cc2ncnc(Nc3cccc(c3)C(C)=O)c2cc1NC1CN(C1)C(=O)C=C

InChI Key: InChIKey=WIRGZYXZMXHDLS-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 330411   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor [T790M,L858R] (Homo sapiens (Human))	BDBM330411 ( N4-(3-acetylphenyl)-N6-(1-acryloylazetidin-3-yl)-...) Show SMILES COc1cc2ncnc(Nc3cccc(c3)C(C)=O)c2cc1NC1CN(C1)C(=O)C=C Show InChI InChI=1S/C23H23N5O3/c1-4-22(30)28-11-17(12-28)26-20-9-18-19(10-21(20)31-3)24-13-25-23(18)27-16-7-5-6-15(8-16)14(2)29/h4-10,13,17,26H,1,11-12H2,2-3H3,(H,24,25,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.30	n/a	n/a	n/a	n/a	n/a	n/a
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD. US Patent					Assay Description EGFR, EGFR (T790M, L858R), HER2 kinase were expressed and purified through an insect cell expression system by the Department of Biology, Centaurus B...				US Patent US9725439 (2017) BindingDB Entry DOI: 10.7270/Q2FQ9ZQ9
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM330411 ( N4-(3-acetylphenyl)-N6-(1-acryloylazetidin-3-yl)-...) Show SMILES COc1cc2ncnc(Nc3cccc(c3)C(C)=O)c2cc1NC1CN(C1)C(=O)C=C Show InChI InChI=1S/C23H23N5O3/c1-4-22(30)28-11-17(12-28)26-20-9-18-19(10-21(20)31-3)24-13-25-23(18)27-16-7-5-6-15(8-16)14(2)29/h4-10,13,17,26H,1,11-12H2,2-3H3,(H,24,25,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD. US Patent					Assay Description EGFR, EGFR (T790M, L858R), HER2 kinase were expressed and purified through an insect cell expression system by the Department of Biology, Centaurus B...				US Patent US9725439 (2017) BindingDB Entry DOI: 10.7270/Q2FQ9ZQ9
					More data for this Ligand-Target Pair