BDBM332574 (2E)-3-(3,4-dichlorophenyl)-1-{7-[(4-chlorophenyl)carbonyl]-2,7-diazaspiro[3.5]non-2-yl}prop-2-en-1-one::US10196369, Compound C29

SMILES: Clc1ccc(cc1)C(=O)N1CCC2(CN(C2)C(=O)\C=C\c2ccc(Cl)c(Cl)c2)CC1

InChI Key: InChIKey=GBEBIXNJJBEKHT-KRXBUXKQSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 332574   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
G-protein coupled receptor 183 (Homo sapiens (Human))	BDBM332574 ((2E)-3-(3,4-dichlorophenyl)-1-{7-[(4-chlorophenyl)...) Show SMILES Clc1ccc(cc1)C(=O)N1CCC2(CN(C2)C(=O)\C=C\c2ccc(Cl)c(Cl)c2)CC1 Show InChI InChI=1S/C23H21Cl3N2O2/c24-18-5-3-17(4-6-18)22(30)27-11-9-23(10-12-27)14-28(15-23)21(29)8-2-16-1-7-19(25)20(26)13-16/h1-8,13H,9-12,14-15H2/b8-2+	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE US Patent					Assay Description The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...				US Patent US10196369 (2019) BindingDB Entry DOI: 10.7270/Q2BR8V88
					More data for this Ligand-Target Pair