BDBM33270 azo-sulfonamide, 1e
SMILES: NS(=O)(=O)c1ccc(cc1)\N=N\c1ccc(NCS([O-])(=O)=O)cc1
InChI Key: InChIKey=YIQQXJXUKNXFKX-WUKNDPDISA-M
Data: 7 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Carbonic anhydrase 9 (Homo sapiens (Human)) | BDBM33270 (azo-sulfonamide, 1e) | PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | 5.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Firenze | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem 17: 7093-9 (2009) Article DOI: 10.1016/j.bmc.2009.09.003 BindingDB Entry DOI: 10.7270/Q2M32T4Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 12 (Homo sapiens (Human)) | BDBM33270 (azo-sulfonamide, 1e) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | 6.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Firenze | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem 17: 7093-9 (2009) Article DOI: 10.1016/j.bmc.2009.09.003 BindingDB Entry DOI: 10.7270/Q2M32T4Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 2 (Homo sapiens (Human)) | BDBM33270 (azo-sulfonamide, 1e) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | 105 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze Curated by ChEMBL | Assay Description Inhibition of human cloned full length carbonic anhydrase 2 by stopped flow CO2 hydration assay | Bioorg Med Chem Lett 19: 4929-32 (2009) Article DOI: 10.1016/j.bmcl.2009.07.088 BindingDB Entry DOI: 10.7270/Q2H70GSS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 2 (Homo sapiens (Human)) | BDBM33270 (azo-sulfonamide, 1e) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | 105 | -9.51 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Universita degli Studi di Firenze | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem 17: 7093-9 (2009) Article DOI: 10.1016/j.bmc.2009.09.003 BindingDB Entry DOI: 10.7270/Q2M32T4Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 1 (Homo sapiens (Human)) | BDBM33270 (azo-sulfonamide, 1e) | PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | 106 | -9.51 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Universita degli Studi di Firenze | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem 17: 7093-9 (2009) Article DOI: 10.1016/j.bmc.2009.09.003 BindingDB Entry DOI: 10.7270/Q2M32T4Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic Anhydrase (mtCA 1) (Mycobacterium tuberculosis) | BDBM33270 (azo-sulfonamide, 1e) | PDB MMDB KEGG B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | 6.78E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze Curated by ChEMBL | Assay Description Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase Rv1284 by stopped flow CO2 hydration assay | Bioorg Med Chem Lett 19: 4929-32 (2009) Article DOI: 10.1016/j.bmcl.2009.07.088 BindingDB Entry DOI: 10.7270/Q2H70GSS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) (Mycobacterium tuberculosis) | BDBM33270 (azo-sulfonamide, 1e) | KEGG GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | 8.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze Curated by ChEMBL | Assay Description Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase Rv3273 by stopped flow CO2 hydration assay | Bioorg Med Chem Lett 19: 4929-32 (2009) Article DOI: 10.1016/j.bmcl.2009.07.088 BindingDB Entry DOI: 10.7270/Q2H70GSS | |||||||||||
More data for this Ligand-Target Pair |