BDBM332701 US10196378, Compound C04
SMILES: CN1CCN(Cc2ccc(NC(=O)Nc3ccc(Nc4ccc5ncccc5c4)cc3)cc2C(F)(F)F)CC1
InChI Key: InChIKey=ZCSPZLWIKBOUKI-UHFFFAOYSA-N
Data: 5 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase ABL1 (Homo sapiens (Human)) | BDBM332701 (US10196378, Compound C04) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent | Assay Description The biochemical assays were carried out using the non-phosphorylated kinase domain of c-Abl, Bcr-Abl in Ba/F3 cells is in the phosphorylated state. | US Patent US10196378 (2019) BindingDB Entry DOI: 10.7270/Q2ZG6VCP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 (Homo sapiens (Human)) | BDBM332701 (US10196378, Compound C04) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent | Assay Description The biochemical assays were carried out using the non-phosphorylated kinase domain of c-Abl, Bcr-Abl in Ba/F3 cells is in the phosphorylated state. | US Patent US10196378 (2019) BindingDB Entry DOI: 10.7270/Q2ZG6VCP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM332701 (US10196378, Compound C04) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent | Assay Description The biochemical assays were carried out using the non-phosphorylated kinase domain of c-Abl, Bcr-Abl in Ba/F3 cells is in the phosphorylated state. | US Patent US10196378 (2019) BindingDB Entry DOI: 10.7270/Q2ZG6VCP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
c-abl (Y253F) (Homo sapiens (Human)) | BDBM332701 (US10196378, Compound C04) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 50 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent | Assay Description The biochemical assays were carried out using the non-phosphorylated kinase domain of c-Abl, Bcr-Abl in Ba/F3 cells is in the phosphorylated state. | US Patent US10196378 (2019) BindingDB Entry DOI: 10.7270/Q2ZG6VCP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM332701 (US10196378, Compound C04) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 4.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent | Assay Description The biochemical assays were carried out using the non-phosphorylated kinase domain of c-Abl, Bcr-Abl in Ba/F3 cells is in the phosphorylated state. | US Patent US10196378 (2019) BindingDB Entry DOI: 10.7270/Q2ZG6VCP | |||||||||||
More data for this Ligand-Target Pair |