Found 4 hits for monomerid = 332893 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Non-receptor tyrosine-protein kinase TYK2
(Homo sapiens (Human)) | BDBM332893
(US10196390, Compound I-182)Show SMILES Fc1cccc(F)c1-c1cc(Nc2ccc(cn2)N2CCC(F)(F)CC2)c2C(=O)NCc2n1 Show InChI InChI=1S/C23H19F4N5O/c24-14-2-1-3-15(25)20(14)16-10-17(21-18(30-16)12-29-22(21)33)31-19-5-4-13(11-28-19)32-8-6-23(26,27)7-9-32/h1-5,10-11H,6-9,12H2,(H,29,33)(H,28,30,31) | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 0.0810 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sunesis Pharmaceuticals, Inc.
Curated by ChEMBL
| |
Bioorg Med Chem Lett 15: 983-7 (2005)
Article DOI: 10.1016/j.bmcl.2022.128891 BindingDB Entry DOI: 10.7270/Q2P84GV3 |
More data for this Ligand-Target Pair | |
Non-receptor tyrosine-protein kinase TYK2
(Homo sapiens (Human)) | BDBM332893
(US10196390, Compound I-182)Show SMILES Fc1cccc(F)c1-c1cc(Nc2ccc(cn2)N2CCC(F)(F)CC2)c2C(=O)NCc2n1 Show InChI InChI=1S/C23H19F4N5O/c24-14-2-1-3-15(25)20(14)16-10-17(21-18(30-16)12-29-22(21)33)31-19-5-4-13(11-28-19)32-8-6-23(26,27)7-9-32/h1-5,10-11H,6-9,12H2,(H,29,33)(H,28,30,31) | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| <10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Nimbus Lakshmi, Inc.
US Patent
| Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech... |
US Patent US10196390 (2019)
BindingDB Entry DOI: 10.7270/Q22809Q4 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM332893
(US10196390, Compound I-182)Show SMILES Fc1cccc(F)c1-c1cc(Nc2ccc(cn2)N2CCC(F)(F)CC2)c2C(=O)NCc2n1 Show InChI InChI=1S/C23H19F4N5O/c24-14-2-1-3-15(25)20(14)16-10-17(21-18(30-16)12-29-22(21)33)31-19-5-4-13(11-28-19)32-8-6-23(26,27)7-9-32/h1-5,10-11H,6-9,12H2,(H,29,33)(H,28,30,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 55 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Nimbus Lakshmi, Inc.
US Patent
| |
US Patent US10196390 (2019)
BindingDB Entry DOI: 10.7270/Q22809Q4 |
More data for this Ligand-Target Pair | |
Non-receptor tyrosine-protein kinase TYK2
(Homo sapiens (Human)) | BDBM332893
(US10196390, Compound I-182)Show SMILES Fc1cccc(F)c1-c1cc(Nc2ccc(cn2)N2CCC(F)(F)CC2)c2C(=O)NCc2n1 Show InChI InChI=1S/C23H19F4N5O/c24-14-2-1-3-15(25)20(14)16-10-17(21-18(30-16)12-29-22(21)33)31-19-5-4-13(11-28-19)32-8-6-23(26,27)7-9-32/h1-5,10-11H,6-9,12H2,(H,29,33)(H,28,30,31) | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 83 | n/a | n/a | n/a | n/a | n/a | n/a |
Sunesis Pharmaceuticals, Inc.
Curated by ChEMBL
| |
Bioorg Med Chem Lett 15: 983-7 (2005)
Article DOI: 10.1016/j.bmcl.2022.128891 BindingDB Entry DOI: 10.7270/Q2P84GV3 |
More data for this Ligand-Target Pair | |