BDBM33395 2,4-diaminofuro[2,3-d]pyrimidine, 1b::Z-isomer
SMILES: COc1ccccc1\C(C)=C/c1coc2nc(N)nc(N)c12
InChI Key: InChIKey=JXICVPBZQSPDOK-CLFYSBASSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM33395 (2,4-diaminofuro[2,3-d]pyrimidine, 1b | Z-isomer) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Duquesne University | Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D... | Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM33395 (2,4-diaminofuro[2,3-d]pyrimidine, 1b | Z-isomer) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 1.52E+5 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Duquesne University | Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D... | Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Platelet-derived growth factor receptor beta (Homo sapiens (Human)) | BDBM33395 (2,4-diaminofuro[2,3-d]pyrimidine, 1b | Z-isomer) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 3.03E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University | Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D... | Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate Reductase (DHFR) (Pneumocystis carinii) | BDBM33395 (2,4-diaminofuro[2,3-d]pyrimidine, 1b | Z-isomer) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University | Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ... | Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Homo sapiens (Human)) | BDBM33395 (2,4-diaminofuro[2,3-d]pyrimidine, 1b | Z-isomer) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University | Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ... | Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Dihydrofolate reductase (Rattus norvegicus (rat)) | BDBM33395 (2,4-diaminofuro[2,3-d]pyrimidine, 1b | Z-isomer) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 1.02E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University | Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ... | Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Dihydrofolate reductase (Mus musculus (Mouse)) | BDBM33395 (2,4-diaminofuro[2,3-d]pyrimidine, 1b | Z-isomer) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 3.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University | Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ... | Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Dihydrofolate reductase (DHFR) (Toxoplasma gondii) | BDBM33395 (2,4-diaminofuro[2,3-d]pyrimidine, 1b | Z-isomer) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 3.94E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University | Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ... | Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167 | |||||||||||
More data for this Ligand-Target Pair |