BDBM335409 US10717738, Example 309::US9732085, 309::methyl[4-(2-{(3S)-7-[5-methyl-2-(1H-tetrazol-1-yl)phenyl]-5-oxo-1,2,3,5-tetrahydro-3-indolizinyl}-1H-imidazol-5-yl)phenyl]carbamate

SMILES: COC(=O)Nc1ccc(cc1)-c1cnc([nH]1)[C@@H]1CCc2cc(cc(=O)n12)-c1cc(C)ccc1-n1cnnn1

InChI Key: InChIKey=CRVBQXTYVJQCPM-DEOSSOPVSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 335409   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Coagulation factor XI (Homo sapiens (Human))	BDBM335409 (US10717738, Example 309 | US9732085, 309 | methyl[...) Show SMILES COC(=O)Nc1ccc(cc1)-c1cnc([nH]1)[C@@H]1CCc2cc(cc(=O)n12)-c1cc(C)ccc1-n1cnnn1 Show InChI InChI=1S/C27H24N8O3/c1-16-3-9-23(34-15-29-32-33-34)21(11-16)18-12-20-8-10-24(35(20)25(36)13-18)26-28-14-22(31-26)17-4-6-19(7-5-17)30-27(37)38-2/h3-7,9,11-15,24H,8,10H2,1-2H3,(H,28,31)(H,30,37)/t24-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.30	n/a	n/a	n/a	n/a	n/a	n/a
ONO PHARMACEUTICAL CO., LTD. US Patent					Assay Description Human Factor XIa activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6000, 50 mM HEPES-NaOH (pH7.4) wit...				US Patent US10717738 (2020)
					More data for this Ligand-Target Pair
Coagulation factor XI (Homo sapiens (Human))	BDBM335409 (US10717738, Example 309 | US9732085, 309 | methyl[...) Show SMILES COC(=O)Nc1ccc(cc1)-c1cnc([nH]1)[C@@H]1CCc2cc(cc(=O)n12)-c1cc(C)ccc1-n1cnnn1 Show InChI InChI=1S/C27H24N8O3/c1-16-3-9-23(34-15-29-32-33-34)21(11-16)18-12-20-8-10-24(35(20)25(36)13-18)26-28-14-22(31-26)17-4-6-19(7-5-17)30-27(37)38-2/h3-7,9,11-15,24H,8,10H2,1-2H3,(H,28,31)(H,30,37)/t24-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.30	n/a	n/a	n/a	n/a	n/a	n/a
ONO PHARMACEUTICAL CO., LTD. US Patent					Assay Description Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...				US Patent US9732085 (2017) BindingDB Entry DOI: 10.7270/Q25X2C2P
					More data for this Ligand-Target Pair