BDBM335640 US9732093, Compound 149::tert-Butyl [2-({2-[3-(5-aminopyrazin-2- yl)-6-cyclobutyl-2- fluorophenoxy]pyrimidin-4- yl}amino)ethyl]carbamate

SMILES: CC(C)(C)OC(=O)NCCNc1cc(Oc2c(F)c(ccc2C2CCC2)-c2cnc(N)cn2)ncn1

InChI Key: InChIKey=JPMKRRHPRXNEOO-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 335640   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Flap endonuclease 1 (Homo sapiens (Human))	BDBM335640 (US9732093, Compound 149 | tert-Butyl [2-({2-[3-(5-...) Show SMILES CC(C)(C)OC(=O)NCCNc1cc(Oc2c(F)c(ccc2C2CCC2)-c2cnc(N)cn2)ncn1 Show InChI InChI=1S/C25H30FN7O3/c1-25(2,3)36-24(34)29-10-9-28-20-11-21(33-14-32-20)35-23-16(15-5-4-6-15)7-8-17(22(23)26)18-12-31-19(27)13-30-18/h7-8,11-15H,4-6,9-10H2,1-3H3,(H2,27,31)(H,29,34)(H,28,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM335640 (US9732093, Compound 149 | tert-Butyl [2-({2-[3-(5-...) Show SMILES CC(C)(C)OC(=O)NCCNc1cc(Oc2c(F)c(ccc2C2CCC2)-c2cnc(N)cn2)ncn1 Show InChI InChI=1S/C25H30FN7O3/c1-25(2,3)36-24(34)29-10-9-28-20-11-21(33-14-32-20)35-23-16(15-5-4-6-15)7-8-17(22(23)26)18-12-31-19(27)13-30-18/h7-8,11-15H,4-6,9-10H2,1-3H3,(H2,27,31)(H,29,34)(H,28,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair