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BDBM335709 5-(Ethyl(tetrahydro-2H-pyran-4- yl)amino)-N-((5-fluoro-1-methyl- 3-oxo-1,2,3,4- tetrahydroisoquinolin-4- yl)methyl)-4-methyl-4'- (morpholinomethyl)-[1,1'- biphenyl]-3-carboxamide::US9738630, Example 5

SMILES: CCN(C1CCOCC1)c1cc(cc(C(=O)NCC2C(=O)NC(C)c3cccc(F)c23)c1C)-c1ccc(CN2CCOCC2)cc1

InChI Key: InChIKey=FUYGRYVZMCQDEP-UHFFFAOYSA-N

Data: 1 EC50

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 335709   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))		BDBM335709
PNG
(5-(Ethyl(tetrahydro-2H-pyran-4- yl)amino)-N-((5-fl...)
Show SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCC2C(=O)NC(C)c3cccc(F)c23)c1C)-c1ccc(CN2CCOCC2)cc1
Show InChI InChI=1S/C37H45FN4O4/c1-4-42(29-12-16-45-17-13-29)34-21-28(27-10-8-26(9-11-27)23-41-14-18-46-19-15-41)20-31(24(34)2)36(43)39-22-32-35-30(6-5-7-33(35)38)25(3)40-37(32)44/h5-11,20-21,25,29,32H,4,12-19,22-23H2,1-3H3,(H,39,43)(H,40,44)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<5.00E+3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of hitone methyl transferases can be readily tested by assays known to those sk...

US Patent US9738630 (2017)


BindingDB Entry DOI: 10.7270/Q23X88R2
More data for this
Ligand-Target Pair