BDBM335717 5-(Ethyl(tetrahydro-2H-pyran-4- yl)amino)-N-((8-fluoro-1-methyl- 3-oxo-2,3-dihydroisoquinolin-4- yl)methyl)-4-methyl-4'- (morpholinomethyl)-[1,1'- biphenyl]-3-carboxamide::US9738630, Example 12
SMILES: CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c3cccc(F)c3c(C)[nH]c2=O)c1C)-c1ccc(CN2CCOCC2)cc1
InChI Key: InChIKey=AELNQLUHQWVZNC-UHFFFAOYSA-N
Data: 1 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM335717 (5-(Ethyl(tetrahydro-2H-pyran-4- yl)amino)-N-((8-fl...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <5.00E+3 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as inhibitors of hitone methyl transferases can be readily tested by assays known to those sk... | US Patent US9738630 (2017) BindingDB Entry DOI: 10.7270/Q23X88R2 | |||||||||||
More data for this Ligand-Target Pair |