BDBM335723 2,2-Dimethyl-N-((1-methyl-3- oxo-2,3-dihydroisoquinolin-4- yl)methyl)-7-(6-(piperazin-1- yl)pyridin-3-yl)-2,3- dihydrobenzofuran-5- carboxamide::US9738630, Example 17
SMILES: Cc1[nH]c(=O)c(CNC(=O)c2cc3CC(C)(C)Oc3c(c2)-c2ccc(nc2)N2CCNCC2)c2ccccc12
InChI Key: InChIKey=ZUSPPJRHONBPFB-UHFFFAOYSA-N
Data: 1 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM335723 (2,2-Dimethyl-N-((1-methyl-3- oxo-2,3-dihydroisoqui...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <5.00E+3 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as inhibitors of hitone methyl transferases can be readily tested by assays known to those sk... | US Patent US9738630 (2017) BindingDB Entry DOI: 10.7270/Q23X88R2 | |||||||||||
More data for this Ligand-Target Pair |