BDBM335835 6-[3-(5-Aminopyrazin-2-yl)-6- cyclobutyl-2-fluorophenoxy]pyridazin- 3-amine::US9732093, Compound 338

SMILES: Nc1ccc(Oc2c(F)c(ccc2C2CCC2)-c2cnc(N)cn2)nn1

InChI Key: InChIKey=ZLCUVUBNTLUTDA-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 335835   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Flap endonuclease 1 (Homo sapiens (Human))	BDBM335835 (6-[3-(5-Aminopyrazin-2-yl)-6- cyclobutyl-2-fluorop...) Show SMILES Nc1ccc(Oc2c(F)c(ccc2C2CCC2)-c2cnc(N)cn2)nn1 Show InChI InChI=1S/C18H17FN6O/c19-17-12(13-8-23-15(21)9-22-13)5-4-11(10-2-1-3-10)18(17)26-16-7-6-14(20)24-25-16/h4-10H,1-3H2,(H2,20,24)(H2,21,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair