BDBM336803 (S)-2-(4-(4-chloro-2-fluoro- phenoxy)phenyl)-6-(((2- oxopyrrolidin)-3-yl)amino)-methyl)pyrimidine- 4-carboxamide::US9745287, Compound 15
SMILES: NC(=O)c1cc(CNC2CCNC2=O)nc(n1)-c1ccc(Oc2ccc(Cl)cc2F)cc1
InChI Key: InChIKey=RKBWCMDLEUTQPV-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM336803 ((S)-2-(4-(4-chloro-2-fluoro- phenoxy)phenyl)-6-(((...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 41 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue Pharma L.P. US Patent | Assay Description Cells Manual Electrophysiology: The hNav1.7 expressing HEK-293 cells are plated on 35 mm culture dishes pre-coated with poly-D-lysine in standard DME... | US Patent US9745287 (2017) BindingDB Entry DOI: 10.7270/Q2SJ1NRC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM336803 ((S)-2-(4-(4-chloro-2-fluoro- phenoxy)phenyl)-6-(((...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 65 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue Pharma L.P. US Patent | Assay Description Assay Buffer: The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL... | US Patent US9745287 (2017) BindingDB Entry DOI: 10.7270/Q2SJ1NRC | |||||||||||
More data for this Ligand-Target Pair |