BDBM337002 US9745291, Compound 48::US9765068, Compound 48

SMILES: OC(CNC(=O)COc1cccc2ccc(nc12)N1CCOCC1)CN1CCc2ccccc2C1

InChI Key: InChIKey=PPQNVYHXOFBLNC-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 337002   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM337002 (US9745291, Compound 48 | US9765068, Compound 48) Show SMILES OC(CNC(=O)COc1cccc2ccc(nc12)N1CCOCC1)CN1CCc2ccccc2C1 Show InChI InChI=1S/C27H32N4O4/c32-23(18-30-11-10-20-4-1-2-5-22(20)17-30)16-28-26(33)19-35-24-7-3-6-21-8-9-25(29-27(21)24)31-12-14-34-15-13-31/h1-9,23,32H,10-19H2,(H,28,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...				US Patent US9765068 (2017) BindingDB Entry DOI: 10.7270/Q2959KN3
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM337002 (US9745291, Compound 48 | US9765068, Compound 48) Show SMILES OC(CNC(=O)COc1cccc2ccc(nc12)N1CCOCC1)CN1CCc2ccccc2C1 Show InChI InChI=1S/C27H32N4O4/c32-23(18-30-11-10-20-4-1-2-5-22(20)17-30)16-28-26(33)19-35-24-7-3-6-21-8-9-25(29-27(21)24)31-12-14-34-15-13-31/h1-9,23,32H,10-19H2,(H,28,33)	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....				US Patent US9745291 (2017) BindingDB Entry DOI: 10.7270/Q2J1058K
					More data for this Ligand-Target Pair