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SMILES: OC(CNC(=O)COc1ccccc1-c1cc[nH]n1)CN1CCc2ccccc2C1
InChI Key:
| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Protein arginine N-methyltransferase 5 (Homo sapiens (Human)) | BDBM337004 (US9745291, Compound 50 | US9765068, Compound 50) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet  | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Epizyme, Inc. US Patent | Assay Description Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan... | US Patent US9765068 (2017) BindingDB Entry DOI: 10.7270/Q2959KN3 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human)) | BDBM337004 (US9745291, Compound 50 | US9765068, Compound 50) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Epizyme, Inc. US Patent | Assay Description The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use.... | US Patent US9745291 (2017) BindingDB Entry DOI: 10.7270/Q2J1058K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
