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SMILES: CN1CCc2c(C1)cccc2OCC(=O)NCC(O)CN1CCc2ccccc2C1

InChI Key: InChIKey=ZZKVUCNLXVGLLG-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 337053   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM337053 (US9745291, Compound 99 | US9765068, Compound 99) Show SMILES CN1CCc2c(C1)cccc2OCC(=O)NCC(O)CN1CCc2ccccc2C1 Show InChI InChI=1S/C24H31N3O3/c1-26-11-10-22-20(14-26)7-4-8-23(22)30-17-24(29)25-13-21(28)16-27-12-9-18-5-2-3-6-19(18)15-27/h2-8,21,28H,9-17H2,1H3,(H,25,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...				US Patent US9765068 (2017) BindingDB Entry DOI: 10.7270/Q2959KN3
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM337053 (US9745291, Compound 99 | US9765068, Compound 99) Show SMILES CN1CCc2c(C1)cccc2OCC(=O)NCC(O)CN1CCc2ccccc2C1 Show InChI InChI=1S/C24H31N3O3/c1-26-11-10-22-20(14-26)7-4-8-23(22)30-17-24(29)25-13-21(28)16-27-12-9-18-5-2-3-6-19(18)15-27/h2-8,21,28H,9-17H2,1H3,(H,25,29)	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....				US Patent US9745291 (2017) BindingDB Entry DOI: 10.7270/Q2J1058K
					More data for this Ligand-Target Pair