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SMILES: Nc1cnc(cn1)-c1ccc(cc1F)-c1ccc(nc1S(=O)(=O)C1CCS(=O)(=O)CC1)C(F)(F)F

InChI Key: InChIKey=APWAMVPHSSHDTH-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 337627   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Flap endonuclease 1


(Homo sapiens (Human))		BDBM337627
PNG
(5-(4-{2-[(1,1-Dioxidotetrahydra-2H- thiopyran-4-yl...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccc(nc1S(=O)(=O)C1CCS(=O)(=O)CC1)C(F)(F)F
Show InChI InChI=1S/C21H18F4N4O4S2/c22-16-9-12(1-2-15(16)17-10-28-19(26)11-27-17)14-3-4-18(21(23,24)25)29-20(14)35(32,33)13-5-7-34(30,31)8-6-13/h1-4,9-11,13H,5-8H2,(H2,26,28)
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PC cid
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US Patent
 0.5n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...

US Patent US9745328 (2017)


BindingDB Entry DOI: 10.7270/Q2H13446
More data for this
Ligand-Target Pair