BDBM338400 8-[3-fluoro-4-[[3S,6R)-3-methyl- 1,1-dioxo-6-phenyl-thiazinan-2- yl]methyl]phenyl]-1,3-dimethyl- 1,3,8-triazaspiro[4.5]decane-2,4- dione::US9751873, Example 88

SMILES: C[C@H]1CC[C@H](c2ccccc2)S(=O)(=O)C1Cc1ccc(cc1F)N1CCC2(CC1)N(C)C(=O)N(C)C2=O

InChI Key: InChIKey=URFSGUBVRWEWLR-ZPVXWVENSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 338400   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human))	BDBM338400 (8-[3-fluoro-4-[[3S,6R)-3-methyl- 1,1-dioxo-6-pheny...) Show SMILES C[C@H]1CC[C@H](c2ccccc2)S(=O)(=O)C1Cc1ccc(cc1F)N1CCC2(CC1)N(C)C(=O)N(C)C2=O |r| Show InChI InChI=1S/C28H34FN3O4S/c1-19-9-12-24(20-7-5-4-6-8-20)37(35,36)25(19)17-21-10-11-22(18-23(21)29)32-15-13-28(14-16-32)26(33)30(2)27(34)31(28)3/h4-8,10-11,18-19,24-25H,9,12-17H2,1-3H3/t19-,24+,25?/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.90	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description Assays were carried out in 16-microL reaction volumes in black 384 Plus F Proxiplates (Perkin-Elmer 6008269). All assay components except test ligand...				US Patent US9751873 (2017) BindingDB Entry DOI: 10.7270/Q2BC41NZ
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