BDBM338469 (7R)-2-[[2-fluoro-4-[(1R,5S)-6- (1,2,4-triazol-4-yl)-3- azabicyclo[3.1.0]hexan-3- yl]phenyl]methyl]-7-phenyl- thiazepane 1,1-dioxide::US9751873, Example 156
SMILES: Fc1cc(ccc1CN1CCCC[C@H](c2ccccc2)S1(=O)=O)N1C[C@H]2[C@@H](C1)[C@@H]2n1cnnc1
InChI Key: InChIKey=STRFPQBEKAOMPI-OUMDNPPYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM338469 ((7R)-2-[[2-fluoro-4-[(1R,5S)-6- (1,2,4-triazol-4-y...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech, Inc. US Patent | Assay Description Assays were carried out in 16-microL reaction volumes in black 384 Plus F Proxiplates (Perkin-Elmer 6008269). All assay components except test ligand... | US Patent US9751873 (2017) BindingDB Entry DOI: 10.7270/Q2BC41NZ | |||||||||||
More data for this Ligand-Target Pair |